R.F.S., F.D.M., T.L., C.H.M., W.C.H., M.R.D.B., and J.M.S. contributed equally to this work.
Females with FVIII and FIX deficiency have reduced joint range of motion
Version of Record online: 21 MAY 2014
© 2014 Wiley Periodicals, Inc.
American Journal of Hematology
Volume 89, Issue 8, pages 831–836, August 2014
How to Cite
Sidonio, R. F., Mili, F. D., Li, T., Miller, C. H., Hooper, W. C., DeBaun, M. R., Soucie, M. and The Hemophilia Treatment Centers Network (2014), Females with FVIII and FIX deficiency have reduced joint range of motion. Am. J. Hematol., 89: 831–836. doi: 10.1002/ajh.23754
Conflicts of interest: Robert Sidonio, Jr. has participated in advisory boards for Grifols, CSL Behring, Baxter, Biogen, and Kedrion. The authors stated that they had no interests, which might be perceived as posing a conflict or bias.
- Issue online: 14 JUL 2014
- Version of Record online: 21 MAY 2014
- Accepted manuscript online: 17 MAY 2014 01:33AM EST
- Manuscript Accepted: 28 APR 2014
- Manuscript Revised: 21 APR 2014
- Manuscript Received: 16 APR 2014
- NCRR/NIH (Vanderbilt CTSA). Grant Number: UL1 RR024975
- The Cooperative Agreement DD06-005
- The Centers for Disease Control and Prevention
- The Vanderbilt Clinical and Translational Research Scholars (VCTRS) KL2 Program, and Grifols
Little is known about rates of joint bleeding among females with FVIII/FIX deficiency or hemophilia carriers. In a cross-sectional study, we tested the hypothesis that females with FVIII or FIX deficiency enrolled in the Universal Data Collection (UDC) project had a reduced mean overall joint range of motion (ROM) compared with historic controls from the Normal Joint Study. Demographics, clinical characteristics, and joint ROM measurements on 303 females without a bleeding disorder and 148 females with FVIII and FIX deficiency, respectively, between the ages of 2–69 years and a body mass index (BMI) ≤ 35 were compared. Multivariate linear regression was performed with the overall joint ROM (sum of the right and left ROM measurements of five joints) as the dependent variable and FVIII or FIX activity as the independent variable adjusting for age, race, BMI, and number of joint bleeds reported over the last 6 months. As FVIII and FIX activity decreased, the mean overall joint ROM became reduced and in most cases was significantly lower than that of the controls regardless of age and clinical hemophilia severity. Further investigation of reduced joint ROM as evidence of subclinical joint bleeding in females with FVIII and FIX deficiency is warranted. Am. J. Hematol. 89:831–836, 2014. © 2014 Wiley Periodicals, Inc.