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Original Article
Effect of zinc supplementation on serum testosterone level in adult male sickle cell anemia subjects
Article first published online: 11 JUL 2006
DOI: 10.1002/ajh.2830100203
Copyright © 1981 Wiley-Liss, Inc., A Wiley Company
1096-8652/asset/cover.gif?v=1&s=d31a603f9c7a1894ee3b68044c6fdcbe64ff8068 "American Journal of Hematology")
Additional Information
How to Cite
Prasad, A. S., Abbasi, A. A., Rabbani, P. and Dumouchelle, E. (1981), Effect of zinc supplementation on serum testosterone level in adult male sickle cell anemia subjects. American Journal of Hematology, 10: 119–127. doi: 10.1002/ajh.2830100203
Publication History
- Issue published online: 11 JUL 2006
- Article first published online: 11 JUL 2006
- Manuscript Accepted: 8 OCT 1980
- Manuscript Received: 10 SEP 1980
Funded by
- Sickle Cell Disease branch of the National Heart and Lung Institute, Bethesda, Maryland
- Abstract
- References
- Cited By
Keywords:
- sickle cell;
- zinc;
- male hypogonadism
Abstract
Previously, we have documented primary testicular failure in adult male subjects with sickle cell anemia. We have also reported the occurrence of zinc deficiency and suggested that androgen deficiency may be related to zinc deficiency in such patients. In this study, we present data with respect to the effect of oral zinc supplementation on serum testosterone levels in adult male patients with sickle cell anemia. An increase in serum testosterone, neutrophil zinc, and neutrophil alkaline phosphatase activity was observed in the zinc-supplemented group in comparison with the group on placebo. Additionally, body weight increased and serum lactic dehydrogenase activity decreased in response to zinc supplementation. We conclude that androgen deficiency in adult male subjects with sickle cell anemia is correctable with zinc supplementation and that the determination of neutrophil zinc and alkaline phosphatase activity in the neutrophils may be utilized as good indicators of body zinc status in such subjects.