Ultrastructural evidence for the origin of mast cells in normal human bone marrow
Version of Record online: 11 JUL 2006
Copyright © 1991 Wiley-Liss, Inc., A Wiley Company
American Journal of Hematology
Volume 38, Issue 1, pages 69–71, September 1991
How to Cite
Saito, N., Takemori, N., Tachibana, N. and Hayashishita, N. (1991), Ultrastructural evidence for the origin of mast cells in normal human bone marrow. Am. J. Hematol., 38: 69–71. doi: 10.1002/ajh.2830380113
- Issue online: 11 JUL 2006
- Version of Record online: 11 JUL 2006
- Manuscript Accepted: 14 MAR 1991
- Manuscript Received: 25 FEB 1991
- Third Department of Internal Medicine, Hokkaido University School of Medicine
- immunogold staining
Whether the origin of the progenitor of mast cells occurs in the basophil/mast cell system or the myeloid cell system of neutrophils and monocytes/macrophages remains controversial.
Lactoferrin or lysozyme is known to be present in the myeloid cell system. By electron microscopy, antibodies against lactoferrin and lysozyme were observed to stain the granules of normal bone marrow mast cells. This supports the proposal that the precursor cell of bone marrow mast cells is nearer to the myeloid cell system than the basophil/mast cell system.