Enhanced platelet reactivity and hypercoagulability in the steady state of sickle cell anaemia

Authors

  • Dr. S. I. Berney,

    Corresponding author
    1. Thrombosis Unit, Department of Haematology, St. Bartholomew's Hospital, West Smithfield, London EC1A 7BE, England
    • Department of Haematology, Barnet General Hospital, Wellhouse Lane, Barnet, Herts EN5 3DJ, England
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  • C. D. Ridler,

    1. Thrombosis Unit, Department of Haematology, St. Bartholomew's Hospital, West Smithfield, London EC1A 7BE, England
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  • A. D. Stephens,

    1. Thrombosis Unit, Department of Haematology, St. Bartholomew's Hospital, West Smithfield, London EC1A 7BE, England
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  • A. E. Thomas,

    1. Thrombosis Unit, Department of Haematology, St. Bartholomew's Hospital, West Smithfield, London EC1A 7BE, England
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  • I. B. Kovacs

    1. Thrombosis Unit, Department of Haematology, St. Bartholomew's Hospital, West Smithfield, London EC1A 7BE, England
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Abstract

A prospective controlled study was undertaken to investigate the haemostatic and coagulation status of 18 adult subjects in the steady state of sickle cell anaemia (SCA), using a relatively new in vitro technique. Shear induced haemostasis, whole blood dynamic coagulation, and spontaneous thrombolysis were measured using nonanticoagulated blood. As expected, the haemoglobin levels were significantly lower and platelet counts significantly higher in subjects with SCA compared with controls. Haemostasis and coagulation were significantly enhanced in SCA. No correlation was found between the raised platelet count and enhanced haemostasis or the reduced haemoglobin and hypercoagulation, respectively. Hyperactivity of the haemostatic system may have a pathogenic role in vaso-occlusive microthrombotic events and in the leg ulcers, both of which occur frequently in SCA. © 1992 Wiley-Liss, Inc.

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