Original Article

Trends in the incidence of polycythemia vera among olmsted county, Minnesota residents, 1935–1989

  1. Dr. Basilio J. Anía1,†,
  2. Vera J. Suman2,
  3. Janet L. Sobell1,
  4. Mary B. Codd1,
  5. Murray N. Silverstein3,
  6. Dr. L. Joseph Melton III1,*

Article first published online: 11 JUL 2006

DOI: 10.1002/ajh.2830470205

Issue

American Journal of Hematology

American Journal of Hematology

Volume 47, Issue 2, pages 89–93, October 1994

Additional Information

How to Cite

Anía, B. J., Suman, V. J., Sobell, J. L., Codd, M. B., Silverstein, M. N. and Melton, L. J. (1994), Trends in the incidence of polycythemia vera among olmsted county, Minnesota residents, 1935–1989. Am. J. Hematol., 47: 89–93. doi: 10.1002/ajh.2830470205

Author Information

  1. 1

    Department of Health Sciences Research, Section of Clinical Epidemiology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota

  2. 2

    Section of Biostatistics, Mayo Clinic and Mayo Foundation, Rochester, Minnesota

  3. 3

    Division of Hematology and Internal Medicine, Mayo Clinic and Mayo Foundation, Rochester, Minnesota

  1. †

    Hospital Ntra. Sra. del Pino, Las Palmas G.C., Spain

*Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN 55905

Publication History

  1. Issue published online: 11 JUL 2006
  2. Article first published online: 11 JUL 2006
  3. Manuscript Accepted: 13 APR 1994
  4. Manuscript Received: 11 OCT 1993

Funded by

  • National Institutes of Health, United States Public Health Service. Grant Number: AR 30582

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Keywords:

  • polycythemia vera;
  • incidence;
  • secular trend;
  • population-based studies

Abstract

To investigate the suggestion that the incidence of polycythemia vera has increased in recent decades, we ascertained secular trends in the incidence of polycythemia vera in Olmsted County, Minnesota, over the 55-year period, 1935–1989. The inpatient and outpatient medical records of all potential cases of polycythemia vera in Olmsted County residents were reviewed and the diagnostic criteria of the Polycythemia Vera Study Group were applied. We found no indication of an increase in the age- and sex-adjusted incidence of polycythemia vera, which averaged 1.9 per 100,000 person-years (95% C.I., 1.4–2.5) over the study period. Incidence rates increased with age, and age-adjusted incidence rates were greater for men (2.8 per 100,000 person-years; 95% C.I., 1.8–3.9) than for women (1.3 per 100,000 person-years; 95% C.I., 0.7–1.9), with the highest incidence rate (23.5 per 100,000 person-years) among men aged 70–79 years. Survival was reduced in this inception cohort of 50 cases, compared to that expected for individuals of like age and sex (P < 0.0001); median survival following diagnosis was 7.2 years. © 1994 Wiley-Liss, Inc.

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