Acquired von willebrand's disease: A rare manifestation of postpartum thyroiditis

Authors

  • Cheryl A. Aylesworth M.D.,

    Corresponding author
    1. Department of Hematology/Oncology, Walter Reed Army Medical Center, National Institutes of Health, Bethesda, Maryland
    • Department of Hematology/Oncology, Brooke Army Medical Center, 1950 Stanley Road, San Antonio, TX 78234–6287
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  • Robert C. Smallridge,

    1. Division of Medicine, National Institutes of Health, Bethesda, Maryland
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  • Margaret E. Rick,

    1. Walter Reed Army Institute of Research, Washington, D.C.; Department of Hematology, Clinical Center, National Institutes of Health, Bethesda, Maryland
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  • Barbara M. Alving

    1. Department of Hematology and Vascular Biology, National Institutes of Health, Bethesda, Maryland
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Abstract

This report describes the diagnosis of acquired type I von Willebrand disease in a 30-year-old woman (G5P5) who presented with complaints of excessive bleeding in the postpartum period. The patient's additional complaints of fatigue, depression, and inability to lose weight resulted in laboratory testing that indicated hypothyroidism due to thyroiditis. Clinical symptoms and laboratory tests for von Willebrand disease and hypothyroidism normalized with L-thyroxine replacement Thyroiditis resulting in symptomatic hypothyroidism occurs in 2–4 per cent of postpartum women. The possibility of underlying hypothyroidism should be considered for those patients, especially if they are parous women, who appear to have an acquired bleeding disorder suggestive of von Willebrand disease.

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