Genetic structure of seven Mexican indigenous populations based on five polymarker loci

Authors

  • Leonora Buentello-Malo,

    1. Instituto de Investigaciónes Antropologicas, Universidad Nacional Autonoma de Mexico, Mexico D.F.
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  • Rosenda I. Peñaloza-Espinosa,

    1. Unidad de Investigacion Médica en Genética Humana, Centro Medico Nacional, Siglo XXI, Instituto Mexicano del Seguro Social (IMSS), México D.F.
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  • Francisco Loeza,

    1. Universidad Michoacana de San Nicolas de Hidalgo, Michoacan, México
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  • Fabio Salamanca-Gomez,

    1. Unidad de Investigacion Médica en Genética Humana, Centro Medico Nacional, Siglo XXI, Instituto Mexicano del Seguro Social (IMSS), México D.F.
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  • Ricardo M. Cerda-Flores

    Corresponding author
    1. Departamento de Genetica de Poblaciones, Centro de Investigación Biomédica del Noreste, IMSS, Nuevo León, México
    2. Facultad de Enfermeria, Universidad Autonoma de Nuevo León, Mexico
    • División de Genética, CIBIN, IMSS, Administración de Correos #4, Apdo. Postal #20, 64720 Monterrey, Nuevo León, México
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Abstract

This descriptive study investigates the genetic structure of seven Mexican indigenous populations (Mixteca Alta, Mixteca Baja, Otomies, Purepecha, Nahuas-Guerrero, Nahuas-Xochimilco, and Tzeltales) on the basis of five PCR-based polymorphic DNA loci: LDLR, GYPA, HBGG, D7S8, and GC. Genetic distance and diversity analyses indicate that these Mexican indigenous are similar and that more than 96% of the total gene diversity (HT) can be attributed to individual variation within populations. Mixteca-Alta, Mixteca-Baja, and Nahuas-Xochimilco show indications of higher admixture with European-derived persons. The demonstration of a relative genetic homogeneity of Mexican Indians for the markers studied suggests that this population is suitable for studying disease-marker associations in the search for candidate genes of complex diseases. Am. J. Hum. Biol. 15:23–28, 2003. © 2002 Wiley-Liss, Inc.

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