Our previous study (Karmakar et al. 2005 Ann. Hum. Biol. 32:445–468) was on 500 pedigrees of five different populations, with factor 1 comprising quantitative finger dermatoglyphics (including pattern intensity index, PII) and factor 1 controlled by major genes. The present results of a complex segregation analysis of the individual trait PII of the same five populations were compared with previous results to ascertain the extent of variation between individual trait PII and its factor (factor 1) with respect to mode of inheritance. The comparative findings are very similar in five populations, irrespective of different ethnic groups. This result suggests that the variability of their biological relevance is influenced by the same genetic component, thus representing a similar mode of inheritance with major gene involvement in all populations. Am. J. Hum. Biol. 18:377–386, 2006. © 2006 Wiley-Liss, Inc.