Population structure and admixture in Cerro Largo, Uruguay, based on blood markers and mitochondrial DNA polymorphisms

Authors

  • Mónica Sans,

    Corresponding author
    1. Departamento de Antropología Biológica, Facultad de Humanidades y Ciencias de la Educación, Universidad de la República, 11200 Montevideo, Uruguay
    • Sección de Antropología Biológica, Facultad de Humanidades y Ciencias de la Educación, Universidad de la República, Magallanes 1577, 11200 Montevideo, Uruguay
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  • D. Andrew Merriwether,

    1. Department of Anthropology, Binghamton University, Binghamton, New York 13850-6000
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  • Pedro C. Hidalgo,

    1. Laboratorio de Inmunogenética e Histocompatibilidad, Instituto Nacional de Donación y Trasplante de Células, Organos y Tejidos, Hospital de Clínicas “Manuel Quintela,” 11600 Montevideo, Uruguay
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  • Nilo Bentancor,

    1. Laboratorio de Inmunogenética e Histocompatibilidad, Instituto Nacional de Donación y Trasplante de Células, Organos y Tejidos, Hospital de Clínicas “Manuel Quintela,” 11600 Montevideo, Uruguay
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  • Tania A. Weimer,

    1. Laboratório de Biotecnologia Veterinária, Universidade Luterana do Brasil, 92110-250 Canoas, Rio Grande do Sul, Brazil
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  • Maria Helena L.P. Franco,

    1. Departamento de Genética, Instituto de Biociências, Universidade Federal do Rio Grande do Sul, 91501-970 Porto Alegre, Rio Grande do Sul, Brazil
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    • Maria Helena L.P. Franco is deceased.

  • Inés Alvarez,

    1. Laboratorio de Inmunogenética e Histocompatibilidad, Instituto Nacional de Donación y Trasplante de Células, Organos y Tejidos, Hospital de Clínicas “Manuel Quintela,” 11600 Montevideo, Uruguay
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  • Brian M. Kemp,

    1. Department of Anthropology, University of California at Davis, Davis, California 95616
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  • Francisco M. Salzano

    1. Departamento de Genética, Instituto de Biociências, Universidade Federal do Rio Grande do Sul, 91501-970 Porto Alegre, Rio Grande do Sul, Brazil
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Abstract

Recent studies of the Uruguayan population revealed different amounts of Amerindian and African genetic contributions. Our previous analysis of Afro-Uruguayans from the capital city of the Department of Cerro Largo showed a high proportion of African genes, and the effects of directional mating involving Amerindian women. In this paper, we extended the analysis to a sample of more than 100 individuals representing a random sample of the population of the whole Department. Based on 18 autosomal markers and one X-linked marker, we estimated 82% European, 8% Amerindian, and 10% African contributions to their ancestry, while from seven mitochondrial DNA site-specific polymorphic markers and sequences of hypervariable segment I, we determined 49% European, 30% Amerindian, and 21% African maternal contributions. Directional matings between Amerindian women and European men were detected, but differences involving Africans were not significant. Data about the specific origins of maternal lineages were also provided, and placed in a historical context. Am. J. Hum. Biol. 18:513–524, 2006. © 2006 Wiley-Liss, Inc.

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