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Original Research
Variation of skeletal biomarkers of biological aging in a Chuvashian population: A longitudinal study
Article first published online: 7 DEC 2006
DOI: 10.1002/ajhb.20582
Copyright © 2006 Wiley-Liss, Inc.
Additional Information
How to Cite
Kalichman, L., Malkin, I., Livshits, G., Pavlovsky, O., Batsevich, V. and Kobyliansky, E. (2007), Variation of skeletal biomarkers of biological aging in a Chuvashian population: A longitudinal study. Am. J. Hum. Biol., 19: 74–81. doi: 10.1002/ajhb.20582
Publication History
- Issue published online: 7 DEC 2006
- Article first published online: 7 DEC 2006
- Manuscript Revised: 8 AUG 2006
- Manuscript Accepted: 8 AUG 2006
- Manuscript Received: 16 JUL 2006
Funded by
- Israel National Science Foundation. Grant Number: 1042-04
- Tel Aviv University. Grant Number: 900010
- Abstract
- References
- Cited By
Abstract
Osseographic score (OSS) is a skeletal biomarker of biological aging, based on assessment of the hand's radiographic features. The aims of the present cross-sectional and follow-up study were: 1) to evaluate age-related changes of OSS in a large Chuvashian cohort, and 2) to evaluate sex differences in age-related changes of OSS. This study reports on intersexual differences in the pattern of skeletal aging. The most prominent difference was in the rate of skeletal change, measured as average OSS difference per year. However, no differences were found in the age at which the first skeletal change occurred. The mean values of OSS were higher in males than in females in decades 3–5 of life, but afterwards they reversed. In a follow-up study, we found that sex differences regarding the rate of OSS change began in the fifth decade, but became statistically significant only in the sixth and seventh decades. Thereafter, the rate of OSS change again became virtually equal between sexes. Am. J. Hum. Biol. 19:74–81, 2007. © 2006 Wiley-Liss, Inc.