Genetic structure of Mexican Mestizo women with breast cancer based on three STR loci
Version of Record online: 17 JAN 2008
Copyright © 2008 Wiley-Liss, Inc.
American Journal of Human Biology
Volume 20, Issue 2, pages 191–193, March/April 2008
How to Cite
Calderón-Garcidueñas, A. L., Rivera-Prieto, R. A., Ortíz-Lopez, R., Rivas, F., Barrera-Saldaña, H. A., Peñaloza-Espinosa, R. I. and Cerda-Flores, R. M. (2008), Genetic structure of Mexican Mestizo women with breast cancer based on three STR loci. Am. J. Hum. Biol., 20: 191–193. doi: 10.1002/ajhb.20713
- Issue online: 13 FEB 2008
- Version of Record online: 17 JAN 2008
- Manuscript Accepted: 19 JUN 2007
- Manuscript Revised: 18 JUN 2007
- Manuscript Received: 3 AUG 2006
- FOFOI. Grant Number: IMSS-2002/021/20111021
- CONACyT, México. Grant Number: 93354
The aim of this population genetics study was to compare the genetic structure of Mexican women with breast cancer (BrCa) with previously reported data of four random populations (Nuevo León, Hispanics, Chihuahua, and Central Region of Mexico). A sample of 115 unrelated women with BrCa and whose four grandparents were born in five zones of Mexico were interviewed at a reference hospital in Northeastern Mexico. Noncodifying STRs D7S820, D13S317, and D16S39 were analyzed; genotype distribution was in agreement with Hardy–Weinberg expectations for all three markers. Similar allele frequencies among four random populations and this selected population were found. According with this and previous studies using molecular and nonmolecular nuclear DNA markers not associated with any disease, Mexican Mestizo population is genetically homogeneous and therefore, genetic causes of BrCa are less heterogeneous, simplifying genetic epidemiologic studies. Am. J. Hum. Biol., 2008. © 2008 Wiley-Liss, Inc.