Original Research Article
Evidence that parent-of-origin affects birth-weight reductions at high altitude
Article first published online: 30 APR 2008
Copyright © 2008 Wiley-Liss, Inc.
American Journal of Human Biology
Volume 20, Issue 5, pages 592–597, September/October 2008
How to Cite
Bennett, A., Sain, S. R., Vargas, E. and Moore, L. G. (2008), Evidence that parent-of-origin affects birth-weight reductions at high altitude. Am. J. Hum. Biol., 20: 592–597. doi: 10.1002/ajhb.20784
- Issue published online: 15 AUG 2008
- Article first published online: 30 APR 2008
- Manuscript Accepted: 19 FEB 2008
- Manuscript Revised: 18 FEB 2008
- Manuscript Received: 17 NOV 2007
- NIH. Grant Numbers: HL079647, TW001188, HL60131
Hypoxia exerts a profound depressant effect on fetal growth, lowering birth weight, and raising mortality risk. Multigenerational high-altitude populations are relatively protected from this birth-weight decline, leading us to hypothesize that genetic factors were involved. We asked if the amount of high- versus low-altitude ancestry influenced birth weight at high altitude and, specifically, whether such influences were affected by parent-of-origin effects (i.e., genomic imprinting). Medical records were reviewed from 1,343 consecutive, singleton deliveries in La Paz, Bolivia (3,600 m) of high- (Andean) or low- (European) altitude ancestry. Parental surnames were used to classify ancestry as Andean, European, Mestizo (“mixed”) or some combination thereof. The effects of population ancestry on birth weight were determined by categorical, conditional linear regression. Babies born at altitude with two Andean parents weighed 252 g more than their European counterparts, with the protective effect being proportional to the amount of Andean parentage and independent of maternal parity, body size, smoking, or socioeconomic status. Paternal compared with maternal transmission raised birth weight 81 g for a given ancestry group. We concluded that indigenous high-altitude ancestry protected against hypoxia-associated fetal growth reduction in a dose-dependent fashion consistent with the involvement of genetic factors. Further, some of the genes involved appeared to be influenced by parent-of-origin effects, given that maternal transmission restricted and paternal transmission enhanced fetal growth. Am. J. Hum. Biol., 2008. © 2008 Wiley-Liss, Inc.