Recurrent mutation in SNPs within Y chromosome E3b (E-M215) haplogroup: A rebuttal
Article first published online: 30 APR 2008
Copyright © 2008 Wiley-Liss, Inc.
American Journal of Human Biology
Volume 20, Issue 5, pages 614–616, September/October 2008
How to Cite
Cruciani, F., Trombetta, B., Novelletto, A. and Scozzari, R. (2008), Recurrent mutation in SNPs within Y chromosome E3b (E-M215) haplogroup: A rebuttal. Am. J. Hum. Biol., 20: 614–616. doi: 10.1002/ajhb.20790
- Issue published online: 15 AUG 2008
- Article first published online: 30 APR 2008
- Manuscript Accepted: 6 MAR 2008
- Manuscript Revised: 28 FEB 2008
- Manuscript Received: 12 FEB 2008
- Grandi Progetti Ateneo, Sapienza Università di Roma
- Italian Ministry of the University - Progetti di Ricerca di Interesse Nazionale 2005. Grant Numbers: 2005057001_002, 2005057001_004
In a previous issue of AJHB, Fernandes et al. (2008. Am J Hum Biol 20:185–190.) describe instances of identity by state at multiple short tandem repeat loci between human Y chromosomes belonging to different E-M35 sub-haplogroups. They interpret these findings as evidence for multiple mutational events in at least two loci (M78 and M81). Here, we introduce a novel polymorphic marker (V68), potentially useful to investigate the issue. This marker and sequence data, reported here for the first time, reinforce our previous interpretations on the phylogenetic structure of the E3b haplogroup. We discuss these results in the frame of general approaches to attain robust phylogenetic inferences based on biallelic polymorphism data. Am. J. Hum. Biol., 2008. © 2008 Wiley-Liss, Inc.