Analysis of TPI gene promoter variation in three sub-Saharan Africa population samples
Article first published online: 12 SEP 2008
Copyright © 2008 Wiley-Liss, Inc.
American Journal of Human Biology
Volume 21, Issue 1, pages 118–120, January 2009
How to Cite
Manco, L., Machado, P., Lopes, D., Nogueira, F., Do Rosário, V. E., Alonso, P. L., Varandas, L., De Jesus Trovoada, M., Amorim, A. and Arez, A. P. (2009), Analysis of TPI gene promoter variation in three sub-Saharan Africa population samples. Am. J. Hum. Biol., 21: 118–120. doi: 10.1002/ajhb.20819
- Issue published online: 5 DEC 2008
- Article first published online: 12 SEP 2008
- Manuscript Accepted: 15 JUL 2008
- Manuscript Revised: 8 JUL 2008
- Manuscript Received: 8 MAY 2008
- CMDT-LA/IHMT (“Prog. de financiamento Plurianual da Unidade de I&D n 58” and POCTI/1999/ESP/35789/99, FCT/MCTES)
- Centro de Investigação em Antropologia e Saúde - Universidade de Coimbra
- Fundação para a Ciência e Tecnologia (through POCI Programa Operacional Ciência e Inovação 2010)
Population samples from Angola, Mozambique, and S. Tomé e Príncipe were screened for the TPI gene promoter variants -5AG, -8GA and -24TG. Three haplotypes were identified in the three populations: the haplotype -5A-8G-24T (average frequency 65.3%) and two less common haplotypes -5G-8G-24T (average frequency 24.7%) and -5G-8A-24T (average frequency 10.0%). A population sample from Central Portugal showed the haplotype -5A-8G-24T in 139 chromosomes and one subject heterozygous for haplotype -5G-8A-24G. The exact test of sample differentiation among three groups of malaria-infected individuals classified according to the severity of the disease showed no significant differences. We confirmed TPI gene diversity in sub-Saharan Africa, but we could not detect any association between TPI promoter variation and a malarial protective effect. Larger scale epidemiological studies are thus required to clarify this putative mechanism of natural host defense against this worldwide public health problem. Am. J. Hum. Biol., 2009. © 2008 Wiley-Liss, Inc.