Original Research Article
Genetic composition of Brazilian population samples based on a set of twenty-eight ancestry informative SNPs
Article first published online: 28 JUL 2009
Copyright © 2009 Wiley-Liss, Inc.
American Journal of Human Biology
Volume 22, Issue 2, pages 187–192, March/April 2010
How to Cite
Lins, T. C., Vieira, R. G., Abreu, B. S., Grattapaglia, D. and Pereira, R. W. (2010), Genetic composition of Brazilian population samples based on a set of twenty-eight ancestry informative SNPs. Am. J. Hum. Biol., 22: 187–192. doi: 10.1002/ajhb.20976
- Issue published online: 30 JAN 2010
- Article first published online: 28 JUL 2009
- Manuscript Accepted: 22 JUN 2009
- Manuscript Revised: 1 JUN 2009
- Manuscript Received: 20 APR 2009
Ancestry informative SNPs can be useful to estimate individual and population biogeographical ancestry. Brazilian population is characterized by a genetic background of three parental populations (European, African, and Brazilian Native Amerindians) with a wide degree and diverse patterns of admixture. In this work we analyzed the information content of 28 ancestry-informative SNPs into multiplexed panels using three parental population sources (African, Amerindian, and European) to infer the genetic admixture in an urban sample of the five Brazilian geopolitical regions. The SNPs assigned apart the parental populations from each other and thus can be applied for ancestry estimation in a three hybrid admixed population. Data was used to infer genetic ancestry in Brazilians with an admixture model. Pairwise estimates of Fst among the five Brazilian geopolitical regions suggested little genetic differentiation only between the South and the remaining regions. Estimates of ancestry results are consistent with the heterogeneous genetic profile of Brazilian population, with a major contribution of European ancestry (0.771) followed by African (0.143) and Amerindian contributions (0.085). The described multiplexed SNP panels can be useful tool for bioanthropological studies but it can be mainly valuable to control for spurious results in genetic association studies in admixed populations. Am. J. Hum. Biol., 2010. © 2009 Wiley-Liss, Inc.