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Estimates of interethnic admixture in the Brazilian population using a panel of 24 X-linked insertion/deletion markers

Authors

  • Rafael Lima Resque,

    1. Laboratório de Genética Humana e Médica, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém, Para, Brazil
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  • Natalle Do Socorro Da Costa Freitas,

    1. Laboratório de Genética Humana e Médica, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém, Para, Brazil
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  • Elzemar Martins Ribeiro Rodrigues,

    1. Laboratório de Genética Humana e Médica, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém, Para, Brazil
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  • João Farias Guerreiro,

    1. Laboratório de Genética Humana e Médica, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém, Para, Brazil
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  • Ney Pereira Carneiro Dos Santos,

    1. Laboratório de Genética Humana e Médica, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém, Para, Brazil
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  • Ândrea Ribeiro Dos Santos,

    1. Laboratório de Genética Humana e Médica, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém, Para, Brazil
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  • Marco Antonio Zago,

    1. Faculdade de Medicina de Ribeirão Preto, Universidade São Paulo, Ribeirão Preto, São Paulo, Brazil
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  • Sidney Santos

    Corresponding author
    1. Laboratório de Genética Humana e Médica, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém, Para, Brazil
    • Laboratório de Genética Humana e Médica, Instituto de Ciências Biológicas, Universidade Federal do Pará, Cidade Universitária Prof. José da Silveira Netto. Av. Augusto Corrêa, 01 Belém, PA, Brazil
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Abstract

Objectives. In this study, we aimed to identify ancestry informative haplotypes and make interethnic admixture estimates using X-chromosome markers.

Methods. A significant sample (461 individuals) of European, African, and Native American populations was analyzed, and four linkage groups were identified. The data obtained were used to describe the ancestral contribution of populations from four different geographical regions of Brazil (745 individuals).

Results. The global interethnic admixture estimates of the four mixed populations under investigation were calculated applying all the 24 insertion/deletion (INDEL) markers. In the North region, a larger Native Americans ancestry was observed (42%). The Northeast and Southeast regions had smaller Native American contribution (27% in both of them). In the South region, there was a large European contribution (46%).

Conclusions. The estimates obtained are compatible with expectations for a colonization model with biased admixture between European men (one X chromosome) and Native American and African women (two X chromosomes), so the 24 X-INDEL panel described here can be a useful to make admixture interethnic estimates in Brazilian populations. Am. J. Hum. Biol., 2010. © 2010 Wiley-Liss, Inc.

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