Positive antibody response to vaccination in adolescence predicts lower C-reactive protein concentration in young adulthood in the philippines

Authors

  • Thomas W. Mcdade,

    Corresponding author
    1. Department of Anthropology, Northwestern University, Evanston, Illinois
    2. Cells to Society (C2S), The Center on Social Disparities and Health, Institute for Policy Research, Northwestern University, Evanston, Illinois
    • Department of Anthropology, Northwestern University, 1810 Hinman Avenue, Evanston, IL 60208, USA
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  • Linda Adair,

    1. Carolina Population Center and Department of Nutrition, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina
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  • Alan B. Feranil,

    1. Office of Population Studies Foundation, University of San Carlos, Cebu City, Philippines
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  • Christopher Kuzawa

    1. Department of Anthropology, Northwestern University, Evanston, Illinois
    2. Cells to Society (C2S), The Center on Social Disparities and Health, Institute for Policy Research, Northwestern University, Evanston, Illinois
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Abstract

Objectives: Inflammation has been associated with a wide range of chronic degenerative diseases, but the developmental factors contributing to the regulation of inflammation are poorly understood. This study investigates the within-individual association between antibody response to vaccination in adolescence and C-reactive protein (CRP) concentration in young adulthood.

Methods: In 1998–99, at age 14–15 years, a subset of participants (N = 96) in the Cebu Longitudinal Health and Nutrition Survey were administered a typhoid vaccine, and baseline and follow-up blood samples were drawn to assess the strength of the antibody response to vaccination. In 2005, at age 20–21 years, blood samples were drawn from the full cohort for measurement of CRP. N = 74 individuals had complete data at both time points. Bivariate associations and multivariate logistic regression models were evaluated to test the hypothesis that vaccine responsiveness in adolescence was significantly associated with CRP level in young adulthood.

Results: There was a strong and statistically significant association between antibody response to vaccination in adolescence and CRP in young adulthood. Median CRP was more than four times higher among nonresponders than responders, and nonresponders were 2.3 to 3.6 times more likely to have CRP in the top tertile of the sample distribution.

Conclusions: This study provides evidence for a prospective, within-individual link between more effective antibody-mediated immune defenses and lower levels of inflammation. In the context of prior research in this population, these results suggest that early environments are important determinants of multiple aspects of an individual's immuno-phenotype. Am. J. Hum. Biol., 2011. © 2010 Wiley-Liss, Inc.

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