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Pubertal muscle mass and diabetes markers in chinese adolescents

Authors

  • Shi Lin Lin,

    1. Life Course and Lifestyle Epidemiology Group, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, People's Republic of China
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  • So Lun Lee,

    1. Queen Mary Hospital, Pokfulam, Hong Kong SAR, People's Republic of China
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  • Lai Ling Hui,

    1. Life Course and Lifestyle Epidemiology Group, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, People's Republic of China
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  • Shiu Lun Au Yeung,

    1. Life Course and Lifestyle Epidemiology Group, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, People's Republic of China
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  • Michael A. Tse,

    1. Institute of Human Performance, The University of Hong Kong, Hong Kong SAR, People's Republic of China
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  • Gabriel M. Leung,

    1. Life Course and Lifestyle Epidemiology Group, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, People's Republic of China
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  • C. Mary. Schooling

    Corresponding author
    1. Life Course and Lifestyle Epidemiology Group, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, People's Republic of China
    • Department of Community Medicine and School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Unit 624-627, Level 6, Core F, Cyberport 3, 100 Cyberport Road, Hong Kong, People's Republic of China
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Abstract

Objectives: Diabetes is common in China despite a relatively nonobese population. We hypothesized that testosterone driven muscle mass acquisition at puberty may be relevant. We examined the associations of testosterone with muscle mass and of muscle mass with fasting glucose in Chinese adolescents.

Methods: In 40 adolescents (20 boys and 20 girls, age 12.9 ± 0.1 years) from Hong Kong's “Children of 1997” birth cohort, we used multivariable linear regression to assess adjusted associations of testosterone and fasting glucose (from a morning blood sample) with muscle and fat mass from a dual-energy X-ray absorptiometry scan.

Results: Testosterone was positively associated with muscle mass (0.05 kg, 95% confidence interval (CI) 0.01 to 0.09, per pg/ml testosterone). Muscle mass was associated with lower glucose (−0.04 mmol/l, 95% CI −0.08 to −0.01 per kg muscle mass) adjusted for sex and fat mass.

Conclusions: Environmentally driven muscle mass acquisition at puberty could influence diabetes. Am. J. Hum. Biol. 2012. © 2012 Wiley Periodicals, Inc.

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