Adenylate kinase genetic polymorphism and spontaneous abortion

Authors

  • Fulvia Gloria-Bottini,

    Corresponding author
    1. Division of Human Populations Biopathology and Environmental Pathology, Department of Biopathology and Imaging Diagnostics, University of Rome Tor Vergata, School of Medicine, Rome, Italy
    • Department of Biopathology and Imaging Diagnostics, University of Rome Tor Vergata, Via Montpellier, 1, 00133 Rome, Italy
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  • Maria Nicotra,

    1. Institute of Gynaecology, Perinatology and Child Disease, University of Rome La Sapienza, School of Medicine, Rome, Italy
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  • Ada Amante,

    1. Division of Human Populations Biopathology and Environmental Pathology, Department of Biopathology and Imaging Diagnostics, University of Rome Tor Vergata, School of Medicine, Rome, Italy
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  • Adalgisa Pietropolli,

    1. Department of Obstetrics and Gynaecology, Univeristy of Rome Tor Vergata, School of Medicine, Rome, Italy
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  • Anna Neri,

    1. Division of Human Populations Biopathology and Environmental Pathology, Department of Biopathology and Imaging Diagnostics, University of Rome Tor Vergata, School of Medicine, Rome, Italy
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  • Egidio Bottini,

    1. Division of Human Populations Biopathology and Environmental Pathology, Department of Biopathology and Imaging Diagnostics, University of Rome Tor Vergata, School of Medicine, Rome, Italy
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  • Andrea Magrini

    1. Division of Human Populations Biopathology and Environmental Pathology, Department of Biopathology and Imaging Diagnostics, University of Rome Tor Vergata, School of Medicine, Rome, Italy
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Abstract

Objective:

Recent studies on healthy puerperae suggest that Adenylate kinase locus 1 (Ak1) genetic polymorphism could be involved in intrauterine selection. In this article, we have searched for a possible relationship between Ak1 polymorphism and spontaneous abortion.

Methods:

178 women with primary repeated spontaneous abortion (RSA), 487 healthy consecutive puerperae, 251 puerperae with diabetes, and 361 consecutive healthy female newborns from the White Caucasian population of Central Italy delivered at the Maternal Department have been studied.

In these subjects, Ak1 phenotype was determined to study the relationship between this enzyme and spontaneous abortion.

Results:

The proportion of Ak12-1 phenotype is higher in women with history of two or more spontaneous abortion than in puerperae with a negative history of spontaneous abortion and in female newborns infants (O.R. 1.930; 95%C.I. 1.113–3.280). Moreover, RSA women carrying the Ak12-1 phenotype have a reduced probability of having live-born infants.

Conclusions:

Our findings suggest a reduced reproductive efficiency of women carrying the Ak12-1 phenotype: this observation could have practical importance in predicting the probability of reproductive success in couples with RSA and in the practice of in vitro fertilization. Am. J. Hum. Biol. 2012. © 2012 Wiley Periodicals, Inc.

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