Expression pattern of the transforming growth factor β signaling genes in human peripheral blood mononuclear cells after exercise—inflammatory aspects




The present study has focused on the identification of differences between the expression pattern of TGF-β signaling pathway genes in athletes after exercise.

Materials and methods:

The study group consisted of three healthy cyclists, which were collected pre-exercise, immediately postexercise, and after 15 min of recovery. The analysis of the expression profile of genes related to the TGF-β signal transduction pathway was performed in peripheral blood mononuclear cells using HG-U133A oligonucleotide microarrays.


A significant differential gene expression was recorded for RUNX3, TGFBR3, MLC1, and GRB2.


The effect of physical exercise on immune response may be essential for human health. Moreover, alterations of TGF-β signaling can be involved in the process of adaptation of human organism to physical exertion. Am. J. Hum. Biol., 2012. © 2012 Wiley Periodicals, Inc.