C-reactive protein by pregnancy and lactational status among Filipino young adult women
Article first published online: 24 NOV 2012
Copyright © 2012 Wiley Periodicals, Inc.
American Journal of Human Biology
Volume 25, Issue 1, pages 131–134, January/February 2013
How to Cite
Kuzawa, C. W., Adair, L. S., Borja, J. and Mcdade, T. W. (2013), C-reactive protein by pregnancy and lactational status among Filipino young adult women. Am. J. Hum. Biol., 25: 131–134. doi: 10.1002/ajhb.22351
- Issue published online: 18 DEC 2012
- Article first published online: 24 NOV 2012
- Manuscript Accepted: 21 OCT 2012
- Manuscript Revised: 15 OCT 2012
- Manuscript Received: 16 APR 2012
- National Institute of Health. Grant Number: R01 HL085144
- Interdisciplinary Obesity Center. Grant Number: RR20649
- Center for Environmental Health and Susceptibility. Grant Number: ES10126; project 7-2004-E
Pregnancy and lactation involve adaptations in immune regulation, but little is known about cross-cultural variation in inflammatory changes during pregnancy or lactation. Here we report concentrations of C-reactive protein (CRP) in a large cross-sectional sample of healthy Filipino women who vary in parity, gestational, and lactational status, and who come from a population previously described as having low CRP.
Fasting plasma CRP was measured among female participants (ages 20.8–22.4 years) in the Cebu Longitudinal Health and Nutrition Survey (n = 822).
Median CRP was 0.2 mg/l in nulliparous women and peaked at 2.0 mg/l in women in their 3rd trimester of pregnancy. Parous but post-partum women had higher CRP compared to nulliparous women, which was largely explained by body composition differences as reflected in waist circumference and skinfold measures. Among post-partum women with infants, CRP was similar in women who were currently breastfeeding compared to those who were not.
At Cebu, women late in gestation have 10-fold higher C-reactive protein compared to nulliparous women, with no evidence that lactation is inflammatory. These population-based findings are similar with findings from prior clinic-based studies and are consistent with the maternal immunological adaptations initiated during pregnancy. The tendency of human females to spend more time than females of other great apes in gestation rather than lactation suggests that the human life history strategy involved increased time spent by reproductively aged females in a pro-inflammatory state. Am. J. Hum. Biol., 2013. © 2012Wiley Periodicals, Inc.