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Association of Self-Reported Familial History of Cardiometabolic Disease with Metabolic Syndrome in Apparently Healthy Urban Colombian Men

Authors

  • Milton F. Suárez-Ortegón,

    Corresponding author
    1. Nutrition Group, University of Valle, Cali, Colombia
    • Physiological Sciences Department, University of Valle, Cali, Colombia
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  • Alejandra Arbeláez,

    1. Physiological Sciences Department, University of Valle, Cali, Colombia
    2. Nutrition Group, University of Valle, Cali, Colombia
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  • Mildrey Mosquera,

    1. Physiological Sciences Department, University of Valle, Cali, Colombia
    2. Nutrition Group, University of Valle, Cali, Colombia
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  • Fabian Méndez,

    1. School of Public Health, University of Valle, Cali, Colombia
    2. Epidemiology and Population Health Group, University of Valle, Cali, Colombia
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  • Alberto Pradilla,

    1. Nutrition Group, University of Valle, Cali, Colombia
    2. School of Public Health, University of Valle, Cali, Colombia
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    • †In memoriam.

  • Cecilia Aguilar-de Plata

    1. Physiological Sciences Department, University of Valle, Cali, Colombia
    2. Nutrition Group, University of Valle, Cali, Colombia
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Correspondence to: Milton F. Suárez-Ortegón, Physiological Sciences Department Universidad del Valle (San Fernando), Calle 4B 36-00, Edificio 116, Quinto piso, Oficina 5503, Cali, Colombia. E-mail: fabian.suarezuv@gmail.com

Abstract

Objectives

Evidence about the relationship between familial history (FH) of cardiometabolic disease (CMD) and metabolic syndrome (MetS) in Latin American populations is scarce. The aim of this study was to evaluate the relationship of FH of CMD and of dyslipidemia and obesity with MetS in healthy men.

Methods

One-hundred-twenty one individuals were recruited. Waist circumference and blood pressure were measured by a trained researcher using standard techniques. Glycemia and lipid profile were determined by colorimetric assays. A survey to record personal data and family antecedents in siblings, aunts/uncles, parents, and grandparents was conducted by trained interviewers.

Results

Individuals having three or more familial antecedents were associated with high triglycerides level even after adjusting by age, sedentarism, fat and carbohydrates intake, and alcohol consumption. After adjusting for the same variables, FH of dyslipidemia and hypertension was also associated with high triglycerides levels and elevated waist circumference, respectively. The FH of stroke was associated with high blood pressure after adjusting for the rest of familial antecedents, and with MetS in all adjustment models.

Discussion

the findings of association of this study together with the previous reports are evidence of the importance of hereditary component as independent predictor of cardiovascular risk factors and its clustering, as well as of possible specific association patterns between FH of CMD and MetS depending on evaluated population in terms of ethnic groups and geographic region. Further studies are required in other populations, as well as exploration of genetic markers of CMD regarding to MetS. Am. J. Hum. Biol. 25:228–230, 2013. © 2013 Wiley Periodicals, Inc.

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