The authors have no conflicts of interest.
Ambulatory blood pressure and blood lipids in a multiethnic sample of healthy adults
Version of Record online: 20 APR 2013
Copyright © 2013 Wiley Periodicals, Inc.
American Journal of Human Biology
Volume 25, Issue 4, pages 563–565, July/August 2013
How to Cite
James, G. D., Van Berge-Landry, H. M., Morrison, L. A., Reza, A. M., Nicolaisen, N. M., Bindon, J. R. and Brown, D. E. (2013), Ambulatory blood pressure and blood lipids in a multiethnic sample of healthy adults. Am. J. Hum. Biol., 25: 563–565. doi: 10.1002/ajhb.22401
- Issue online: 19 JUN 2013
- Version of Record online: 20 APR 2013
- Manuscript Accepted: 6 MAR 2013
- Manuscript Revised: 5 MAR 2013
- Manuscript Received: 21 DEC 2012
- NIH. Grant Number: NIGMS GM08073
Elevated blood pressure (BP), elevated serum cholesterol, and aberrant lipoprotein fractions (low levels of high-density lipoprotein (HDL) and high levels of low-density lipoprotein fractions and triglycerides) have all been used as measures that assess the “metabolic syndrome” and more recently in indexes of allostatic load, which are designed to assess the degree of integrated metabolic pathology. While there are ample data regarding the interrelationships of these measures in various pathophysiological settings, there are limited data regarding the interrelationship of ambulatory BP (ABP) and blood lipids in healthy subjects. The present study evaluates ABP-blood lipid relationships in a multiethnic sample of healthy adults.
The subjects were 37 men (age = 40.9 ± 10.7 years) and 42 women (age = 35.8 ± 10.4 years) who were employed as hotel workers in Hawaii. Each wore an ABP monitor for one midweek workday and had pressures averaged in three daily microenvironments (work, home, and during sleep). They also had fasting blood samples taken for lipid profiling.
Multivariate analysis of covariance shows that there was a strong inverse relationship between HDL and both systolic (P < 0.006) and diastolic (P < 0.006) BP, overall and in each microenvironment, but no statistically significant relationships with other lipid measures.
These results suggest lipids and BP do not act as a group in healthy adults but that higher HDL is associated with lower BP. This latter finding is consistent with research that shows that HDL promotes vasodilation via its effect on endothelial nitric oxide synthase. Am. J. Hum. Biol. 25:563–565, 2013. © 2013 Wiley Periodicals, Inc.