Birth weight, season of birth and postnatal growth do not predict levels of systemic inflammation in gambian adults
Article first published online: 10 JUN 2013
Copyright © 2013 Wiley Periodicals, Inc.
American Journal of Human Biology
Volume 25, Issue 4, pages 457–464, July/August 2013
How to Cite
Richards, A. A., Fulford, A. J., Prentice, A. M. and Moore, S. E. (2013), Birth weight, season of birth and postnatal growth do not predict levels of systemic inflammation in gambian adults. Am. J. Hum. Biol., 25: 457–464. doi: 10.1002/ajhb.22413
- Issue published online: 19 JUN 2013
- Article first published online: 10 JUN 2013
- Manuscript Accepted: 6 MAY 2013
- Manuscript Revised: 30 APR 2013
- Manuscript Received: 1 FEB 2013
- MRC Research Grant. Grant Number: G0500048
- MRC core funding to the International Nutrition Group. Grant Number: MC-A760-5QX00
Studies testing whether systemic inflammation might lie on the causal pathway between aberrant fetal and post-natal growth patterns and later cardiovascular disease have been inconclusive, possibly due to the use of single markers of unknown predictive value. We used repeated measures of a comprehensive set of inflammatory markers to investigate the relationship between early life measures and systemic inflammation in an African population.
Individuals born in three rural villages in The Gambia, and for whom early life measurements were recorded, were traced (n = 320). Fasting levels of eight inflammatory markers (C-reactive protein, serum amyloid A, orosomucoid, fibrinogen, α 1-antichymotrypsin, sialic acid, interleukin-6 and neopterin) were measured, and potential confounding factors recorded. The association between early life measurements and systemic inflammation was assessed using regression analysis.
Levels of most markers were unrelated to early growth patterns. In analyses adjusted for age and sex, more rapid growth between birth and 3 months of age was associated with higher levels of fibrinogen, orosomucoid, and sialic acid. These relationships persisted after further adjustment for body mass index but after full adjustment only the association with fibrinogen remained.
This study provides little evidence that size at birth or growth in early infancy determine levels of inflammatory markers in young Gambian adults. Am. J. Hum. Biol. 25:457–464, 2013. © 2013 Wiley Periodicals, Inc.