The copyright line for this article was changed on 9 December 2015 after original online publication.
Associations between arterial oxygen saturation, body size and limb measurements among high-altitude andean children
Version of Record online: 1 AUG 2013
Copyright © 2014 The Authors. AMERICAN JOURNAL OF HUMAN BIOLOGY Published by Wiley Periodicals, Inc.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
American Journal of Human Biology
Volume 25, Issue 5, pages 629–636, September/October 2013
How to Cite
Pomeroy, E., Stock, J. T., Stanojevic, S., Miranda, J. J., Cole, T. J. and Wells, J. C.K. (2013), Associations between arterial oxygen saturation, body size and limb measurements among high-altitude andean children. Am. J. Hum. Biol., 25: 629–636. doi: 10.1002/ajhb.22422
- Issue online: 26 AUG 2013
- Version of Record online: 1 AUG 2013
- Manuscript Accepted: 1 JUN 2013
- Manuscript Revised: 12 MAY 2013
- Manuscript Received: 28 FEB 2013
- Arts and Humanities Research Council (UK)
- University of Cambridge Centre for Latin American Studies Abbey-Santander Travel Grant
- Junior Research Fellowship, Newnham College, Cambridge (to EP)
- CRONICAS Center of Excellence in Chronic Diseases at the Universidad Peruana Cayetano Heredia, National Heart, Lung and Blood Institute, National Institutes of Health, Department of Health and Human Services (to JJM) . Grant Number: HHSN268200900033C
- Medical Research Council (to TJC) . Grant Number: MR/J004839/1
The relative influences of hypoxia and other environmental stressors on growth at altitude remain unclear. Previous work demonstrated an association between peripheral arterial oxygen saturation (SpO2) and anthropometry (especially tibia length) among Tibetan and Han children at altitude. We investigated whether similar associations exist among Andeans, and the patterning of associations between SpO2 and anthropometry.
Stature, head-trunk height, total upper and lower limb lengths, zeugopod (ulna and tibia) and autopod (hand and foot) lengths were measured in Peruvian children (0.5–14 years) living at >3000 m altitude. SpO2 was measured by pulse oximetry. Anthropometry was converted to internal z scores. Correlation and multiple regression were used to examine associations between anthropometry z scores and SpO2, altitude, or SpO2 adjusted for altitude since altitude is a major determinant of variation in SpO2.
SpO2 and altitude show weak, significant correlations with zeugopod length z scores and still weaker significant correlations with total upper and lower limb length z scores. Correlations with z scores for stature, head-trunk height, or autopod lengths are not significant. Adjusted for altitude, there is no significant association between anthropometry and SpO2.
Associations between SpO2 or altitude and total limb and zeugopod length z scores exist among Andean children. However, the relationships are relatively weak, and while the relationship between anthropometry and altitude may be partly mediated by SpO2, other factors that covary with altitude (e.g., socioeconomic status, health) are likely to influence anthropometry. The results support suggestions that zeugopod lengths are particularly sensitive to environmental stressors. Am. J. Hum. Biol., 25:629–636, 2013. © 2014 The Authors. AMERICAN JOURNAL OF HUMAN BIOLOGY Published by Wiley Periodicals, Inc.