Pathogenic and obesogenic factors associated with inflammation in Chinese children, adolescents and adults
Article first published online: 7 OCT 2013
Copyright © 2013 Wiley Periodicals, Inc.
American Journal of Human Biology
Volume 26, Issue 1, pages 18–28, January/February 2014
How to Cite
Thompson, A. L., Houck, K. M., Adair, L., Gordon-Larsen, P., Du, S., Zhang, B. and Popkin, B. (2014), Pathogenic and obesogenic factors associated with inflammation in Chinese children, adolescents and adults. Am. J. Hum. Biol., 26: 18–28. doi: 10.1002/ajhb.22462
- Issue published online: 20 DEC 2013
- Article first published online: 7 OCT 2013
- Manuscript Accepted: 31 AUG 2013
- Manuscript Revised: 30 AUG 2013
- Manuscript Received: 13 AUG 2013
- NICHD-NRSA Population Research Training. Grant Number: T32 HD007168
- NIH NICHD. Grant Number: K01 HD071948-01
- NIH (data collection and analysis files for the CHNS) . Grant Numbers: R01-HD30880 , DK056350 , and R01-HD38700
- Institute of Nutrition and Food Safety, China Center for Disease Control and Prevention, the Fogarty International Center, NIH and the China-Japan Friendship Hospital, Ministry of Health
- NHLBI . Grant Number: R01HL108427
- The Carolina Population Center . Grant Number: 5 R24 HD050924
Influenced by pathogen exposure and obesity, inflammation provides a critical biological pathway linking changing environments to the development of cardiometabolic disease. This study tests the relative contribution of obesogenic and pathogenic factors to moderate and acute CRP elevations in Chinese children, adolescents and adults.
Data come from 8795 participants in the China Health and Nutrition Study. Age-stratified multinomial logistic models were used to test the association between illness history, pathogenic exposures, adiposity, health behaviors and moderate (1–10 mg/L in children and 3–10 mg/L in adults) and acute (>10mg/L) CRP elevations, controlling for age, sex and clustering by household. Backward model selection was used to assess which pathogenic and obesogenic predictors remained independently associated with moderate and acute CRP levels when accounting for simultaneous exposures.
Overweight was the only significant independent risk factor for moderate inflammation in children (RRR 2.10, 95%CI 1.13-3.89). History of infectious (RRR 1.28, 95%CI 1.08-1.52) and non-communicable (RRR 1.37, 95%CI 1.12-1.69) disease, overweight (RRR 1.66, 95%CI 1.45-1.89) and high waist circumference (RRR 1.63, 95%CI 1.42-1.87) were independently associated with a greater likelihood of moderate inflammation in adults while history of infectious disease (RRR 1.87, 95%CI 1.35-2.56) and overweight (RRR 1.40, 95%CI 1.04-1.88) were independently associated with acute inflammation. Environmental pathogenicity was associated with a reduced likelihood of moderate inflammation, but a greater likelihood of acute inflammation in adults.
These results highlight the importance of both obesogenic and pathogenic factors in shaping inflammation risk in societies undergoing nutritional and epidemiological transitions. Am. J. Hum. Biol. 26:18–28, 2014. © 2013 Wiley Periodicals, Inc.