Ana B. Crujeiras and María Pardo contributed equally to this work
Longitudinal variation of circulating irisin after an energy restriction-induced weight loss and following weight regain in obese men and women
Article first published online: 5 DEC 2013
Copyright © 2013 Wiley Periodicals, Inc.
American Journal of Human Biology
Volume 26, Issue 2, pages 198–207, March/April 2014
How to Cite
Crujeiras, A. B., Pardo, M., Arturo, R.-R., Santiago, N.-C., Zulet, M. A., Martínez, J. A. and Casanueva, F. F. (2014), Longitudinal variation of circulating irisin after an energy restriction-induced weight loss and following weight regain in obese men and women. Am. J. Hum. Biol., 26: 198–207. doi: 10.1002/ajhb.22493
- Issue published online: 19 FEB 2014
- Article first published online: 5 DEC 2013
- Manuscript Accepted: 23 NOV 2013
- Manuscript Revised: 18 NOV 2013
- Manuscript Received: 19 JUN 2013
- CIBERobn. Grant Number: CB06/03
- INTRASALUD project. Grant Number: PI10/02464
- Instituto de Salud Carlos III (ISCIII) and Health Department of the Government of Navarra. Grant Number: 48/2009
- Linea Especial “Nutrition, Obesity and Health,” University of Navarra. Grant Number: LE/97
- ISCIII through a research contract “Sara Borrell”. Grant Number: C09/00365
- CIBER Fisiopatología Obesidad y Nutrición (ISCIII). Grant Number: CB06/03
- Miguel Servet Fellow (ISCIII/SERGAS)
The recently discovered peptide irisin has been hypothesized to be a regulator of body metabolism. The objective of this work was to evaluate whether circulating human irisin levels are modulated by body size and changes in adiposity during an energy restriction treatment and the subsequent weight regain.
A group of 94 obese patients (50 men, 44 women; 49.4 ± 9.4 years; BMI 35.6 ± 4.5 kg/m2) participated in a weight loss program following an 8-week hypocaloric diet (−30% energy expenditure) with a weight maintenance follow-up. The patients were evaluated at 0, 8, and 24 weeks after starting treatment. In addition, 48 normal-weight subjects (16 men, 32 women; 35.71 ± 8.8 years; BMI 22.9 ± 2.2 kg/m2) participated as controls. Plasma irisin, body weight, body composition, and hormones controlling energy homeostasis were measured.
Irisin levels were higher in obese subjects (353.1 ± 18.6 ng/mL) than in those of normal-weight (198.4 ± 7.8 ng/mL; P ≤ 0.001) and were also higher in men (340.9 ± 20 ng/mL) than in women (267.6 ± 12 ng/mL; P < 0.05). Moreover, irisin plasma levels were significantly correlated with high levels of direct and indirect adiposity markers, such as weight, BMI, waist circumference, and fat mass, as measured by bioimpedance, but not with height or leptin levels. Interestingly, irisin levels paralleled body weight reduction after the dietary treatment (week 8) and again returned to the baseline levels at 24 weeks in those patients regaining the lost weight.
Irisin strongly reflects body fat mass, suggesting that the irisin circulating levels are conditioned by adiposity level. Am. J. Hum. Biol. 26:198–207, 2014. © 2013 Wiley Periodicals, Inc.