FGFR1 signaling is associated with the magnitude of morphological integration in human head shape

Authors

  • Tábita Hünemeier,

    1. Departamento de Genética, Instituto de Biociências, Universidade Federal do Rio Grande do Sul. Caixa Postal 15053, Porto Alegre, RS, Brazil
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  • Jorge Gómez-Valdés,

    1. Departamento de Anatomía, Facultad de Medicina, Universidad Nacional Autónoma de México, Circuito Interior, Ciudad Universitaria, México
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  • Soledad De Azevedo,

    1. Centro Nacional Patagónico-CONICET, Puerto Madryn, Argentina
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  • Mirsha Quinto-Sánchez,

    1. Centro Nacional Patagónico-CONICET, Puerto Madryn, Argentina
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  • Luciane Passaglia,

    1. Departamento de Genética, Instituto de Biociências, Universidade Federal do Rio Grande do Sul. Caixa Postal 15053, Porto Alegre, RS, Brazil
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  • Francisco M. Salzano,

    1. Departamento de Genética, Instituto de Biociências, Universidade Federal do Rio Grande do Sul. Caixa Postal 15053, Porto Alegre, RS, Brazil
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  • Gabriela Sánchez-Mejorada,

    1. Departamento de Anatomía, Facultad de Medicina, Universidad Nacional Autónoma de México, Circuito Interior, Ciudad Universitaria, México
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  • Víctor Acuña Alonzo,

    1. Escuela Nacional de Antropología e Historia, México, DF, México
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  • Neus Martínez-Abadías,

    1. EMBL-CRG Systems Biology Research Unit, Barcelona, Spain
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  • Maria-Cátira Bortolini,

    1. Departamento de Genética, Instituto de Biociências, Universidade Federal do Rio Grande do Sul. Caixa Postal 15053, Porto Alegre, RS, Brazil
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    • These authors contributed equally to this work and should be considered as joint last authors.

  • Rolando González-José

    Corresponding author
    1. Centro Nacional Patagónico-CONICET, Puerto Madryn, Argentina
    • Correspondence to: Rolando González-José, Centro Nacional Patagónico-CONICET, Bvd. Brown 2915, U9120ACD Puerto Madryn, Argentina. E-mail: rolando@cenpat.edu.ar

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    • These authors contributed equally to this work and should be considered as joint last authors.


ABSTRACT

Objectives

The head can be used as a model to study complex phenotypes controlled simultaneously by morphological integration (MI) due to common factors, and modular patterns caused by local factors affecting the development and functional demands of specific structures. The fibroblast growth factor and receptor system (FGF/FGFR) participates in cell communication and pattern formation in osseous tissues, among others, and there is compelling evidence from mouse model studies suggesting a role of the FGF/FGFR pathway as a covariance-generating signaling process in head development. Here we use human data to test if specific genetic variants of another gene of this pathway, the FGFR1 gene, can be associated with differences in the integration of the head.

Methods

We explored whether and how three specific variants on FGFR1, previously associated with human cephalic index, influence the pattern and level of head integration of one Native American and one admixed group from Mexico. MI, measured as the intensity of covariation among head traits, was assessed using data from three-dimensional head landmark coordinates taken on 176 individuals.

Results

Individuals carrying the derived allele of the rs4647905:G>C polymorphism present significantly greater levels of head MI, especially in facial structures and on the shape space where the modular portion of the covariation is explicitly removed.

Conclusions

Since FGFR genes present nonconservative and tissue-specific splicing sites, they may have some effect on protein structure and performance likely involved in developmental processes responsible for the magnitude and pattern of MI in the human head. Am. J. Hum. Biol. 26:164–175, 2014. © 2013 Wiley Periodicals, Inc.

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