Organic dust induced inflammation—role of atopy and TLR-4 and CD14 gene polymorphisms
Article first published online: 2 SEP 2005
Copyright © 2005 Wiley-Liss, Inc.
American Journal of Industrial Medicine
Volume 48, Issue 4, pages 302–307, October 2005
How to Cite
Rylander, R. and Michel, O. (2005), Organic dust induced inflammation—role of atopy and TLR-4 and CD14 gene polymorphisms. Am. J. Ind. Med., 48: 302–307. doi: 10.1002/ajim.20205
- Issue published online: 15 SEP 2005
- Article first published online: 2 SEP 2005
- Manuscript Accepted: 27 JUN 2005
- The Swedish Council for Working Life Research, Stockholm, Sweden. Grant Number: 2001-0256
- organic dust;
Polymorphisms in the genes controlling for CD14 and TLR-4 may influence the outcome of endotoxin-induced effects.
Materials and Methods
A study was performed on 146 workers in industries with exposure to organic dust containing endotoxin and 53 controls. Endotoxin exposure was measured at representative work sites. Inflammagenic markers, cytokines, and CD14 and TLR-4 polymorphisms were determined in blood.
Among workers, serum levels of esinophilic cationic protein (ECP) were lower compared to controls and the proportion of atopics was lower. Atopic persons had lower levels of IL-6 and IL-8, both among controls and exposed. IL-6 and ECP values were lower among those with TLR-4 /+896 AG and GG polymorphisms as compared to AA. Among atopic workers with CD-14(−550) polymorphism CC, IL-8 was lower.
The results suggest that CD14 and TLR-4 polymorphisms influence regulators of the inflammation induced by endotoxin in organic dusts. Atopic persons have a lower secretion of certain inflammatory cytokines. Am. J. Ind. Med. 2005. © 2005 Wiley-Liss, Inc.