The work was performed at the National Cancer Institute, Bethesda, MD.
Article first published online: 3 APR 2006
Published 2006 Wiley-Liss, Inc.
American Journal of Industrial Medicine
Volume 49, Issue 6, pages 460–467, June 2006
How to Cite
Baccarelli, A., Khmelnitskii, O., Tretiakova, M., Gorbanev, S., Lomtev, A., Klimkina, I., Tchibissov, V., Averkina, O., Rice, C. and Dosemeci, M. (2006), Risk of lung cancer from exposure to dusts and fibers in Leningrad Province, Russia. Am. J. Ind. Med., 49: 460–467. doi: 10.1002/ajim.20316
This article is a US Government work and, as such, is in the public domain in the United States of America.
- Issue published online: 8 MAY 2006
- Article first published online: 3 APR 2006
- Manuscript Accepted: 27 FEB 2006
- glass wool;
- linen dust;
- man-made vitreous fibers;
- paper dust;
Exposures to several dusts and fibers (DFs) have been established or suggested as etiologic factors for lung cancer.
To investigate lung cancer risk in relation to exposure to DFs, we identified 540 pathologically-diagnosed lung cancer cases and 582 controls from the 1993–1998 autopsy records of the 88 hospitals of Leningrad Province, Russia. Lifetime job-specific exposure measurements were available for 15 organic, 15 man-made and 28 natural-inorganic agents.
In male workers, increased risks were found for linen dust (OR = 3.68, 95% CI 1.00–13.6, adjusted for age, smoking and residence), and unspecified DFs (OR = 1.44, 95% CI 1.07–1.94). Small non-significant excess risks were observed for quartz dust (OR = 1.27; 95% CI 0.83–1.93) and man-made vitreous fibers (MMVFs) (OR = 1.82, 95% CI 0.88–3.75). In female subjects, risks were non-significantly associated with paper dust (OR = 1.77, 95% CI 0.74–4.20), and unspecified DFs (OR = 1.52, 95% CI 0.77–3.03).
The study showed increased lung cancer risk for selected categories of DFs. Am. J. Ind. Med. 2006. Published 2006 Wiley-Liss, Inc.