Research Article

Shared occupational risks for transitional cell cancer of the bladder and renal pelvis among men and women in Sweden†

  1. Robin Taylor Wilson PhD1,*,
  2. Mark Donahue BS2,
  3. Gloria Gridley MS2,
  4. Johanna Adami MD3,
  5. Laure El ghormli MS4,
  6. Mustafa Dosemeci PhD2

Article first published online: 7 DEC 2007

DOI: 10.1002/ajim.20522

Issue

American Journal of Industrial Medicine

American Journal of Industrial Medicine

Volume 51, Issue 2, pages 83–99, February 2008

Additional Information

How to Cite

Wilson, R. T., Donahue, M., Gridley, G., Adami, J., ghormli, L. E. and Dosemeci, M. (2008), Shared occupational risks for transitional cell cancer of the bladder and renal pelvis among men and women in Sweden. American Journal of Industrial Medicine, 51: 83–99. doi: 10.1002/ajim.20522

Author Information

  1. 1

    Penn State Cancer Institute, Penn State College of Medicine, Hershey, Pennsylvania

  2. 2

    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland

  3. 3

    Department of Medicine, Clinical Epidemiology Unit, Karolinska Institutet, Stockholm, Sweden

  4. 4

    Department of Biostatistics, George Washington University, Washington, District of Columbia

*Epidemiology Division, Department of Health Evaluation Sciences, Penn State College of Medicine, 600 Centerview Drive, Suite 2200, Mail Code A210, Hershey, PA 17033-0855.

  1. †

    The authors do not presently have affiliations with organizations that have a direct financial interest in the subject matter or materials discussed.

Publication History

  1. Issue published online: 10 JAN 2008
  2. Article first published online: 7 DEC 2007
  3. Manuscript Accepted: 13 AUG 2007

Funded by

  • National Cancer Institute, Division of Cancer Epidemiology and Genetics

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Keywords:

  • epidemiology;
  • bladder neoplasms;
  • kidney neoplasms;
  • occupational exposure;
  • industry

Abstract

Background

Unlike cancer of the bladder, cancer of the renal pelvis is not considered an occupational cancer and little is known about risks among women.

Methods

Using the Swedish national census and cancer registry-linked data (1971–1989), we identified transitional cell cancers of the renal pelvis (N = 1,374) and bladder (N = 21,591). Correlation between cancer sites for the standardized incidence ratios (SIR) were determined using Pearson's coefficient of the log SIR. Relative risks of job exposure matrix variables were calculated using Poisson regression.

Results

Both cancer sites were significantly elevated among women and men employed in the machine/electronics industry, sedentary work, and indoor work, and men in the metal industry. The highest proportion of the bladder (12%) and renal pelvis (14%) cancers occurred among men employed in shop and construction metal work. Risks by industry were more correlated among women (r = 0.49, P = 0.002) than men (r = 0.24, P = 0.04). Cancers of the renal pelvis were elevated in several occupational and industry groups for which there was no elevated bladder cancer risk.

Conclusion

Cancers of the renal pelvis and bladder share common occupational risk factors that may be more frequent among women. In addition, there may be some jobs that pose an increased risk specifically for cancer of the renal pelvis but not bladder. Am. J. Ind. Med. 51:83–99, 2008. © 2007 Wiley-Liss, Inc.

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