Occupational risk factors for endometrial cancer among textile workers in Shanghai, China
Article first published online: 14 JUL 2008
Copyright © 2008 Wiley-Liss, Inc.
American Journal of Industrial Medicine
Volume 51, Issue 9, pages 673–679, September 2008
How to Cite
Wernli, K. J., Ray, R. M., Gao, D. L., Fitzgibbons, E. D., Camp, J. E., Astrakianakis, G., Seixas, N., Li, W., De Roos, A. J., Feng, Z., Thomas, D. B. and Checkoway, H. (2008), Occupational risk factors for endometrial cancer among textile workers in Shanghai, China. Am. J. Ind. Med., 51: 673–679. doi: 10.1002/ajim.20614
- Issue published online: 4 AUG 2008
- Article first published online: 14 JUL 2008
- Manuscript Accepted: 30 MAY 2008
- US National Cancer Institute. Grant Number: R01 CA80180
- National Institute of Environmental Health Sciences. Grant Number: ES07262
- endometrial cancer;
A case-cohort study was conducted to investigate associations between occupational exposures and endometrial cancer nested within a large cohort of textile workers in Shanghai, China.
The study included 176 incident endometrial cancer cases diagnosed from 1989 to 1998 and a randomly-selected age-stratified reference subcohort (n = 3,061). Study subjects' complete work histories were linked to a job-exposure matrix developed specifically for the textile industry to assess occupational exposures. Hazard ratios (HR) and 95% confidence intervals were calculated using Cox proportional hazards modeling adapted for the case-cohort design, adjusting for age at menarche and a composite variable of gravidity and parity.
An increased risk of endometrial cancer was detected among women who had worked for ≥10 years in silk production (HR = 3.8, 95% CI 1.2–11.8) and had exposure to silk dust (HR = 1.7, 95% CI 0.9–3.4). Albeit with few exposed women (two cases and eight subcohort women), there was a 7.4-fold increased risk associated with ≥10 years of silica dust exposure (95% CI 1.4–39.7).
The findings suggest that some textile industry exposures might play a role in endometrial carcinoma and should be further replicated in other occupational settings. Am. J. Ind. Med. 51:673–679, 2008. Published 2008 Wiley-Liss, Inc.