SEARCH

SEARCH BY CITATION

Keywords:

  • occupational;
  • rhodium;
  • asthma;
  • allergy

Abstract

Background

Whereas platinum salts are well known occupational allergens, rhodium salts have not been identified as inhalative sensitizing substances.

Methods

A 27-year-old atopic operator of an electroplating plant developed work-related shortness of breath and runny nose with sneezing after exposure to rhodium salts. Quantitative skin prick tests (SPT) and bronchial challenge tests with a dosimeter protocol were performed with quadrupling doses of the sodium chloride salts of rhodium (Na3RhCl6) and platinum (Na2PtCl6).

Results

The patient showed positive SPT reactions and positive bronchial immediate-type reactions with rhodium and platinum salts. Sensitivity to rhodium salt was much higher than to platinum salt; the molar concentrations differed by a factor of 256 in SPT and a factor of 16 in bronchial challenges.

Conclusions

Rhodium salts should be considered as occupational immediate-type allergens. Am. J. Ind. Med. 53:42–46. 2010. © 2009 Wiley-Liss, Inc.