Occupational asbestos exposure as a risk factor for laryngeal carcinoma in a population-based case–control study from Germany
Version of Record online: 2 MAY 2011
Copyright © 2011 Wiley-Liss, Inc.
American Journal of Industrial Medicine
Volume 54, Issue 7, pages 510–514, July 2011
How to Cite
Ramroth, H., Ahrens, W., Dietz, A. and Becher, H. (2011), Occupational asbestos exposure as a risk factor for laryngeal carcinoma in a population-based case–control study from Germany. Am. J. Ind. Med., 54: 510–514. doi: 10.1002/ajim.20963
- Issue online: 31 MAY 2011
- Version of Record online: 2 MAY 2011
- Manuscript Accepted: 6 APR 2011
- German Ministry of Education and Research. Grant Number: 01GB9702/3
- laryngeal cancer;
- occupational exposure;
- detailed measurement methods
As several studies have identified asbestos exposure as an independent occupational risk factor for laryngeal cancer, the aim of our study was to confirm this association.
In a population-based case–control study on laryngeal cancer in South-West Germany occupational exposures and other risk factors were obtained by face-to-face interviews using a detailed standardized questionnaire covering the complete individual working history, supplemented by job-specific questionnaires (JSQ) especially for selected jobs known to entail exposure to asbestos. Detailed exposure information was collected over a wide range of asbestos related jobs and branches and analyzed using different modeling strategies.
Seventy-three (28.4%) cases and 158 (20.5%) controls reported any exposure to asbestos. Elevated risk estimates for asbestos exposure were found. However, those became substantially reduced after adjustment for smoking and alcohol.
Moderately elevated risks for laryngeal cancer after exposure to asbestos were confirmed. Difficulties in the collection of adequate exposure data were demonstrated. Am. J. Ind. Med. 54:510–514, 2011. © 2011 Wiley-Liss, Inc.