Disclosure Statement: The authors report no conflicts of interest.
Article first published online: 10 OCT 2011
Copyright © 2011 Wiley Periodicals, Inc.
American Journal of Industrial Medicine
Volume 55, Issue 1, pages 25–36, January 2012
How to Cite
Pinkerton, L. E., Waters, M. A., Hein, M. J., Zivkovich, Z., Schubauer-Berigan, M. K. and Grajewski, B. (2012), Cause-specific mortality among a cohort of U.S. flight attendants. Am. J. Ind. Med., 55: 25–36. doi: 10.1002/ajim.21011
The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the National Institute for Occupational Safety and Health.
- Issue published online: 7 DEC 2011
- Article first published online: 10 OCT 2011
- Manuscript Accepted: 29 AUG 2011
- Office of Women's Health of the U.S. Department of Health and Human Services (partial support)
- flight attendants;
- cosmic radiation;
- circadian rhythm disruption
We evaluated mortality among 11,311 former U.S. flight attendants. The primary a priori outcomes of interest were breast cancer and melanoma.
Vital status was ascertained through 2007, and life table analyses was conducted. Cumulative exposure to cosmic radiation and circadian rhythm disruption were estimated from work history data and historical published flight schedules.
All-cause mortality was less than expected among women but was elevated among men, primarily due to elevated HIV-related disease mortality. Mortality from breast cancer among women and melanoma was neither significantly elevated nor related to metrics of exposure. Mortality was elevated for non-Hodgkin's lymphoma among men; for alcoholism, drowning, and intentional self-harm among women; and for railway, water, and air transportation accidents.
We found no evidence of increased breast cancer or melanoma mortality. Limitations include reliance on mortality data and limited power resulting from few melanoma deaths and relatively short employment durations. Am. J. Ind. Med. 55:25–36, 2012. © 2011 Wiley Periodicals, Inc.