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Plasma fibrinogen: A possible link between job stress and cardiovascular disease among Chinese workers

Authors

  • Weixian Xu MD, PhD,

    1. Department of Cardiology, Peking University Third Hospital and Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China
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  • Juan Hang MD,

    1. Department of Cardiology, Peking University Third Hospital and Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China
    2. Department of Geriatrics, Peking University Shenzhen Hospital, Shenzhen, China
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  • Lijun Guo MD,

    1. Department of Cardiology, Peking University Third Hospital and Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China
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  • Yiming Zhao PhD,

    1. Research Center of Occupational Medicine, Peking University Third Hospital, Beijing, China
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  • Zhaoping Li MD,

    1. Department of Cardiology, Peking University Third Hospital and Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China
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  • Wei Gao MD

    Corresponding author
    1. Department of Cardiology, Peking University Third Hospital and Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China
    • Department of Cardiology, Peking University Third Hospital, No 49 North Garden Road, Haidian District, Beijing 100191, China.
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Abstract

Background

Little is known about the effect of effort–reward imbalance (ERI) on fibrinogen. We aimed to examine the association between ERI and fibrinogen among Chinese workers.

Methods

A total of 732 subjects without vascular diseases were analyzed. Associations between job stress evaluated by ERI model and plasma fibrinogen were explored by multiple regression.

Results

Effort, overcommitment, and ERI were significantly positively associated with fibrinogen, while reward was negatively related with fibrinogen both for men and for women. Compared with low level group, high level of effort, overcommitment, and ERI significantly increased risk of elevated fibrinogen (more than mean concentration) with adjusted OR of 3.3, 12.5, and 7.7 for men; 2.9, 7.2, and 7.2 for women, respectively; however, high reward reduced 80% risk for elevated fibrinogen.

Conclusions

Effort, overcommitment, and ERI are significantly associated with fibrinogen among Chinese workers. High fibrinogen may be a possible link between job stress and cardiovascular disease. Am. J. Ind. Med. 55:167–175, 2012. © 2011 Wiley Periodicals, Inc.

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