Conflicts of interest: None
Variations in peak expiratory flow measurements associated to air pollution and allergic sensitization in children in Sao Paulo, Brazil†
Article first published online: 27 APR 2012
Copyright © 2012 Wiley Periodicals, Inc.
American Journal of Industrial Medicine
Special Issue: Research Contributions from the United States International Training and Research in Environmental and Occupational Health Program: Part 1
Volume 55, Issue 12, pages 1087–1098, December 2012
How to Cite
Correia-Deur, J. E. d. M., Claudio, L., Imazawa, A. T. and Eluf-Neto, J. (2012), Variations in peak expiratory flow measurements associated to air pollution and allergic sensitization in children in Sao Paulo, Brazil. Am. J. Ind. Med., 55: 1087–1098. doi: 10.1002/ajim.22060
- Issue published online: 7 NOV 2012
- Article first published online: 27 APR 2012
- Manuscript Accepted: 6 APR 2012
- Mount Sinai School of Medicine ITREOH Program
- Fogarty International Center of the National Institutes of Health. Grant Number: 1 D43 TW000640
- air pollution/adverse effects;
- peak expiratory flow;
- allergic sensitization;
- linear models;
In the last 20 years, there has been an increase in the incidence of allergic respiratory diseases worldwide and exposure to air pollution has been discussed as one of the factors associated with this increase. The objective of this study was to investigate the effects of air pollution on peak expiratory flow (PEF) and FEV1 in children with and without allergic sensitization.
Ninety-six children were followed from April to July, 2004 with spirometry measurements. They were tested for allergic sensitization (IgE, skin prick test, eosinophilia) and asked about allergic symptoms. Air pollution, temperature, and relative humidity data were available.
Decrements in PEF were observed with previous 24-hr average exposure to air pollution, as well as with 3–10-day average exposure and were associated mainly with PM10, NO2, and O3 in all three categories of allergic sensitization. Even though allergic sensitized children tended to present larger decrements in the PEF measurements they were not statistically different from the non-allergic sensitized. Decrements in FEV1 were observed mainly with previous 24-hr average exposure and 3-day moving average.
Decrements in PEF associated with air pollution were observed in children independent from their allergic sensitization status. Their daily exposure to air pollution can be responsible for a chronic inflammatory process that might impair their lung growth and later their lung function in adulthood. Am. J. Ind. Med. 55:1087–1098, 2012. © 2012 Wiley Periodicals, Inc.