Disclosure Statement: The authors report no conflicts of interests.
Ischemic heart disease mortality and PM3.5 in a cohort of autoworkers†
Article first published online: 31 DEC 2012
Copyright © 2012 Wiley Periodicals, Inc.
American Journal of Industrial Medicine
Volume 56, Issue 3, pages 317–325, March 2013
How to Cite
Costello, S., Garcia, E., Hammond, S. K. and Eisen, E. A. (2013), Ischemic heart disease mortality and PM3.5 in a cohort of autoworkers. Am. J. Ind. Med., 56: 317–325. doi: 10.1002/ajim.22152
- Issue published online: 19 FEB 2013
- Article first published online: 31 DEC 2012
- Manuscript Accepted: 6 DEC 2012
- Department of Health and Human Services, Centers for Disease Control/National Institute for Occupational Safety and Health. Grant Number: R01 OH008927
- heart disease;
- particulate matter;
- cohort study;
- metalworking fluid
Increased risk of ischemic heart disease (IHD) has been associated with particulate matter (PM) from air pollution. Yet evidence of increased risk associated with higher workplace exposures is scant.
We examined the exposure–response relationship between IHD mortality and PM3.5 (<3.5 µm diameter) from current and cumulative exposure to straight metalworking fluid in a cohort of 39,412 autoworkers followed from 1941 to 1995. Age, calendar year of follow up, sex, race, and plant were included in each model.
To address the decrease in polycyclic-aromatic hydrocarbon (PAH) content in the straight metalworking fluid over time, analyses were stratified by calendar time. Increased risk of IHD mortality was associated with current exposure to PM3.5 before 1971 and with cumulative exposure to PM3.5 after 1971.
Results provide modest evidence that occupational exposure to fine PM from straight fluids, especially fluid with higher PAH, may increase the risk of IHD mortality. Am. J. Ind. Med. 56:317–325, 2013. © 2012 Wiley Periodicals, Inc.