Disclosure Statement: The authors report no conflicts of interests. This work was performed by Federal Government employees as part of their work; no non-governmental funding supported this work.
Letter To The Editor
Markers of upper airway inflammation associated with microbial exposure and symptoms in occupants of a water-damaged building
Article first published online: 6 FEB 2013
Copyright © 2013 Wiley Periodicals, Inc.
American Journal of Industrial Medicine
Volume 56, Issue 5, pages 522–530, May 2013
How to Cite
Akpinar-Elci, M., White, S. K., Siegel, P. D., Park, J.-H., Visotcky, A., Kreiss, K. and Cox-Ganser, J. M. (2013), Markers of upper airway inflammation associated with microbial exposure and symptoms in occupants of a water-damaged building. Am. J. Ind. Med., 56: 522–530. doi: 10.1002/ajim.22165
The findings and conclusions in this report are those of the author(s) and do not necessarily represent the views of the National Institute for Occupational Safety and Health.
Mention of any company or product does not constitute endorsement by NIOSH.
- Issue published online: 16 APR 2013
- Article first published online: 6 FEB 2013
- Manuscript Accepted: 9 JAN 2013
- Federal Government Employees
- building-related symptoms;
- indoor air quality;
- nasal lavage;
- nasal nitric oxide
Water damage in buildings has been associated with reports of upper airway inflammation among occupants.
This survey included a questionnaire, allergen skin testing, nasal nitric oxide, and nasal lavage on 153 participants. We conducted exposure assessments of 297 workstations and analyzed collected dust for fungi, endotoxin, and (1 3)-β-D-glucan to create floor-specific averages.
Males had higher levels of nasal inflammatory markers, and females reported more symptoms. ECP, IL-8, and MPO were significantly associated with nasal symptoms, flu-like achiness, or chills. Fungi and glucan were positively associated with blowing out thick mucus. Endotoxin was significantly associated with ECP in overall models, and with ECP, IL-8, MPO, and neutrophils among non-atopic females.
In this study, we documented an association between endotoxin and nasal inflammatory markers among office workers. The results of our study suggest that a non-allergic response may contribute to symptoms occurring among occupants in this water-damaged building. Am. J. Ind. Med. 56:522–530, 2013. © 2013 Wiley Periodicals, Inc.