Disclaimer: The findings and conclusions in this report are those of the author(s) and do not necessarily represent the views of the National Institute for Occupational Safety and Health.
Cohort mortality study of garment industry workers exposed to formaldehyde: Update and internal comparisons
Article first published online: 20 JUN 2013
Copyright © 2013 Wiley Periodicals, Inc.
American Journal of Industrial Medicine
Volume 56, Issue 9, pages 1027–1039, September 2013
How to Cite
Meyers, A. R., Pinkerton, L. E. and Hein, M. J. (2013), Cohort mortality study of garment industry workers exposed to formaldehyde: Update and internal comparisons. Am. J. Ind. Med., 56: 1027–1039. doi: 10.1002/ajim.22199
Disclosure Statement: The authors report no conflicts of interests.
- Issue published online: 14 AUG 2013
- Article first published online: 20 JUN 2013
- Manuscript Accepted: 27 MAR 2013
- cohort studies;
- occupational exposure;
- retrospective studies;
To further evaluate the association between formaldehyde and leukemia, we extended follow-up through 2008 for a cohort mortality study of 11,043 US formaldehyde-exposed garment workers.
We computed standardized mortality ratios and standardized rate ratios stratified by year of first exposure, exposure duration, and time since first exposure. Associations between exposure duration and rates of leukemia and myeloid leukemia were further examined using Poisson regression models.
Compared to the US population, myeloid leukemia mortality was elevated but overall leukemia mortality was not. In internal analyses, overall leukemia mortality increased with increasing exposure duration and this trend was statistically significant.
We continue to see limited evidence of an association between formaldehyde and leukemia. However, the extended follow-up did not strengthen previously observed associations. In addition to continued epidemiologic research, we recommend further research to evaluate the biological plausibility of a causal relation between formaldehyde and leukemia. Am. J. Ind. Med. 56:1027–1039, 2013. © 2013 Wiley Periodicals, Inc.