High hsCRP is associated with reduced lung function in structural firefighters

Authors

  • Denise M. Gaughan SD,

    1. Department of Preventive Medicine, Institute for Translational Epidemiology, Icahn School of Medicine at Mount Sinai, New York, New York
    2. Department of Environmental Health (Environmental and Occupational Medicine and Epidemiology Program), Harvard School of Public Health, Boston, Massachusetts
    Search for more papers by this author
  • David C. Christiani MD, MPH, MS,

    1. Department of Environmental Health (Environmental and Occupational Medicine and Epidemiology Program), Harvard School of Public Health, Boston, Massachusetts
    Search for more papers by this author
  • Michael D. Hughes PhD,

    1. Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts
    Search for more papers by this author
  • Dorothee M. Baur MD, Msc,

    1. Department of Environmental Health (Environmental and Occupational Medicine and Epidemiology Program), Harvard School of Public Health, Boston, Massachusetts
    Search for more papers by this author
  • Lester Kobzik MD,

    1. Department of Environmental Health (Molecular and Integrative Physiological Sciences), Harvard School of Public Health, Boston, Massachusetts
    Search for more papers by this author
  • Gregory R. Wagner MD,

    1. Department of Environmental Health (Environmental and Occupational Medicine and Epidemiology Program), Harvard School of Public Health, Boston, Massachusetts
    Search for more papers by this author
  • Stefanos N. Kales MD, MPH

    Corresponding author
    1. Department of Environmental Health (Environmental and Occupational Medicine and Epidemiology Program), Harvard School of Public Health, Boston, Massachusetts
    • Correspondence to: Stefanos N. Kales, Department of Environmental Health (Environmental and Occupational Medicine and Epidemiology Program), Building 1, Room 1407, Harvard School of Public Health, Boston, MA. E-mail: skales@hsph.harvard.edu

    Search for more papers by this author

  • Disclosure Statement: The authors report no conflicts of interests.

Abstract

Background

To assess the association between markers of systemic inflammation and pulmonary function in a population of structural firefighters.

Methods

We studied male career members of a large Midwestern fire department with questionnaires, spirometry, and high-sensitivity C-reactive protein (hsCRP) as a biomarker of systemic inflammation. We examined percent predicted forced expiratory volume in 1 s (FEV1%-predicted) and forced vital capacity (FVC%-predicted).

Results

Complete data were available for 401 firefighters. Higher hsCRP levels were associated with lower lung function values, after adjusting for confounding variables. Specifically, for every twofold increase in log10-hsCRP, FEV1%-predicted decreased by a mean 1.5% (95% CI: 0.4, 2.6%) and FVC%-predicted decreased by a mean 1.4% (95% CI: 0.4, 2.3%).

Conclusion

hsCRP as a biomarker of systemic inflammation may indicate reduced lung function in structural firefighters. Am. J. Ind. Med. 57:31–37, 2014. © 2013 Wiley Periodicals, Inc.

Ancillary