Disclosure Statement: The authors report no conflicts of interests.
Retrospective cohort study of a microelectronics and business machine facility
Article first published online: 24 DEC 2013
© 2013 Wiley Periodicals, Inc.
American Journal of Industrial Medicine
Volume 57, Issue 4, pages 412–424, April 2014
How to Cite
Silver, S. R., Pinkerton, L. E., Fleming, D. A., Jones, J. H., Allee, S., Luo, L. and Bertke, S. J. (2014), Retrospective cohort study of a microelectronics and business machine facility. Am. J. Ind. Med., 57: 412–424. doi: 10.1002/ajim.22288
- Issue published online: 5 MAR 2014
- Article first published online: 24 DEC 2013
- Manuscript Accepted: 22 NOV 2013
- National Institute for Occupational Safety and Health (NIOSH)
We examined health outcomes among 34,494 workers employed at a microelectronics and business machine facility 1969–2001.
Standardized mortality ratio (SMR) and standardized incidence ratios were used to evaluate health outcomes in the cohort and Cox regression modeling to evaluate relations between scores for occupational exposures and outcomes of a priori interest.
Just over 17% of the cohort (5,966 people) had died through 2009. All cause, all cancer, and many cause-specific SMRs showed statistically significant deficits. In hourly males, SMRs were significantly elevated for non-Hodgkin's lymphoma and rectal cancer. Salaried males had excess testicular cancer incidence. Pleural cancer and mesothelioma excesses were observed in workers hired before 1969, but no available records substantiate use of asbestos in manufacturing processes. A positive, statistically significant relation was observed between exposure scores for tetrachloroethylene and nervous system diseases.
Few significant exposure–outcome relations were observed, but risks from occupational exposures cannot be ruled out due to data limitations and the relative youth of the cohort. Am. J. Ind. Med. 57:412–424, 2014. © 2013 Wiley Periodicals, Inc.