Association between the COMT locus and obsessive-compulsive disorder in females but not males
Article first published online: 15 NOV 2001
Copyright © 2001 Wiley-Liss, Inc.
American Journal of Medical Genetics
Volume 114, Issue 1, pages 116–120, 8 January 2002
How to Cite
Alsobrook, J. P., Zohar, A. H., Leboyer, M., Chabane, N., Ebstein, R. P. and Pauls, D. L. (2002), Association between the COMT locus and obsessive-compulsive disorder in females but not males. Am. J. Med. Genet., 114: 116–120. doi: 10.1002/ajmg.10040
- Issue published online: 23 OCT 2002
- Article first published online: 15 NOV 2001
- Manuscript Accepted: 2 AUG 2001
- Manuscript Received: 14 DEC 1999
- association study;
- haplotype relative risk;
- transmission disequilibrium;
- sexual dimorphism
A polymorphism in the coding region of catechol-O-methyltransferase gene (COMT) was previously reported to be associated with obsessive-compulsive disorder (OCD), particularly in male probands. We attempted to replicate the previous finding using a family-based genetic design in haplotype relative risk (HRR) and transmission disequilibrium (TDT) analyses. Fifty-six OCD probands and their parents were genotyped for the COMT locus using established methods. Analysis of allele and genotype frequencies between the proband genotypes and the control (parental nontransmitted) genotypes failed to replicate the previous finding of gender divergence, gave no evidence of overall association, nor was linkage detected by TDT. However, further analysis of the COMT allele frequencies by proband gender gave evidence of a mildly significant association with the low-activity COMT allele in female probands (P = 0.049), but not in male probands. These findings indicate that COMT may be etiologically relevant to OCD in a gender-specific manner opposite to that shown in previous studies. © 2001 Wiley-Liss, Inc.