Asymmetry: Molecular, biologic, embryopathic, and clinical perspectives


  • Dr. M. Michael Cohen Jr.

    Corresponding author
    1. Departments of Oral & Maxillofacial Pathology, Pediatrics, Community Health & Epidemiology, Health Services Administration, and Sociology & Social Anthropology, Dalhousie University, Halifax, Nova Scotia, Canada
    • Dalhousie University, Halifax, Nova Scotia, Canada B3H 3J5.
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This overview of asymmetry addresses the following topics: chiral molecules; asymmetric signaling molecules, including N-cadherin, Shh, Fgf8, lefty1, lefty2, nodal, Pitx2, activin βB, activin receptor IIA, and cSnR; situs abnormalities; asymmetric cell division; laterality in humans and animals; behavioral asymmetry in humans and animals; asymmetric embryopathies, including Tessier-type “clefts”; hemiasymmetries such as hemihyperplasia, hemihypoplasia, and hemiatrophy; asymmetric vascular syndromes, including Klippel–Trenaunay and Sturge–Weber syndromes; plagiocephaly of the synostotic and deformational types; somatic mosaicism, including a discussion of McCune–Albright syndrome, fibrous dysplasia, GNAS1 mutations, and Proteus syndrome. © 2001 Wiley-Liss, Inc.