Article

Atrial septal defect, ventricular septal defect, and coarctation of the aorta in sibs: An autosomal recessive disorder?

  1. Dale F. Nordenberg1,
  2. Brian Hanna1,
  3. Jean-Claude Fouron2,
  4. Dr. Vazken M. Der Kaloustian1,3,*,
  5. John M. Opitz Editor,
  6. James F. Reynolds Editor

Article first published online: 5 JUN 2005

DOI: 10.1002/ajmg.1320320208

Issue

American Journal of Medical Genetics

American Journal of Medical Genetics

Volume 32, Issue 2, pages 182–183, February 1989

Additional Information

How to Cite

Nordenberg, D. F., Hanna, B., Fouron, J.-C., Der Kaloustian, V. M., Opitz, J. M. and Reynolds, J. F. (1989), Atrial septal defect, ventricular septal defect, and coarctation of the aorta in sibs: An autosomal recessive disorder?. Am. J. Med. Genet., 32: 182–183. doi: 10.1002/ajmg.1320320208

Author Information

  1. 1

    Department of Pediatrics, McGill University and Division of Medical Genetics, Montreal Children's Hospital, Montreal, Quebec, Canada

  2. 2

    Department of Pediatrics, Université de Montreal and Hôpital Sainte Justine, Montreal, Quebec, Canada

  3. 3

    Department of Centre for Human Genetics, McGill University, Montreal, Quebec, Canada

*Division of Medical Genetics, The Montreal Children's Hospital, 2300 Tupper Street, Montreal, Quebec, H3H 1P3, Canada

Publication History

  1. Issue published online: 5 JUN 2005
  2. Article first published online: 5 JUN 2005
  3. Manuscript Revised: 3 SEP 1988
  4. Manuscript Received: 12 APR 1988

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Keywords:

  • complex cardiac malformation;
  • independent recurrence risk;
  • echocardiography

Abstract

We report on two sisters with secundum atrial septal defect, perimembranous ventricular septal defect, and coarctation of the aorta. Identical anatomical malformations were verified by echocardiography and at operation. No other affected relatives were identified. We suggest that this is a specific, possibly recessively inherited type of complex cardiac malformation.

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