Polyasplenia complex with mesocardia and renal agenesis in an infant of a diabetic mother

Authors

  • Alfonso Gonzalez,

    1. Departments of Pathology, University of Wisconsin, Madison
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  • Natalie Krassikoff,

    1. Pediatrics, University of Wisconsin, Madison
    2. Medical Genetics, University of Wisconsin, Madison
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  • Enid F. Gilbert-Barness M.D.

    Corresponding author
    1. Departments of Pathology, University of Wisconsin, Madison
    2. Pediatrics, University of Wisconsin, Madison
    • Department of Pathology, Clinical Science Center. University of Wisconsin, 600 Highland Ave., Madison, WI 53795
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Abstract

Despite improved prenatal care, infants of diabetic mothers (IDM) have an increased risk of congenital malformations. We report on an IDM with multiple congenital anomalies consistent with the polyasplenia complex with associated mesocardia and renal agenesis. The morphologic characteristics of these malformations are discussed. Special emphasis is given to the polyasplenia complex as an example of midline developmental field defect. The importance of maternal levels of hemoglobin A1c in relation to congenital malformations is addressed.

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