Cerebral palsy in multiple births in Western Australia: Genetic aspects
Article first published online: 6 JUN 2005
Copyright © 1990 Wiley-Liss, Inc., A Wiley Company
American Journal of Medical Genetics
Volume 37, Issue 3, pages 346–351, November 1990
How to Cite
Petterson, B., Stanley, F. and Henderson, D. (1990), Cerebral palsy in multiple births in Western Australia: Genetic aspects. Am. J. Med. Genet., 37: 346–351. doi: 10.1002/ajmg.1320370311
- Issue published online: 6 JUN 2005
- Article first published online: 6 JUN 2005
- Manuscript Revised: 29 MAR 1990
- Manuscript Received: 16 OCT 1989
- motor handicap;
- concordance rate;
- sex ratio
A study of cerebral palsy in multiple births was undertaken to test genetic involvement and assess the impact of the special conditions of pregnancy and parturition in these cases.
Complete ascertainment of cerebral palsy in multiple gestations that occurred in Western Australia between 1956 and 1985 was obtained from the Western Australian Cerebral Palsy Register. There were 74 twins and 5 triplets.
Data on sex, birth order, motor handicap, outcome in co-twins and triplets, zygosity, and pedigree information was obtained from the Register, hospital records, and, where possible, by interview of the parent(s) of the propositi.
There was a significantly higher (P = 0.0026) concordance rate in MZ than in DZ twin pairs. However, pedigree studies showed no other relatives with a motor handicap similar to that of the propositi. This is consistent with a multifactorial cause in at least some of the cases.
The sex ratio of affected twins was found to be 2.1 compared to 1.3 for singletons and all 5 affected triplets were boys. The trend of increasing sex ratio with increasing plurality was significant at the 1% level.