Gastroesophageal dysfunction in Brachmann–de Lange syndrome

Authors

  • Y. Rosenbach,

    1. Division of Pediatric Gastroenterology, Beilinson Medical Center, Petah Tiqva, and the Tel Aviv University Sackler School of Medicine, Tel Aviv, Israel
    Search for more papers by this author
  • I. Zahavi,

    1. Division of Pediatric Gastroenterology, Beilinson Medical Center, Petah Tiqva, and the Tel Aviv University Sackler School of Medicine, Tel Aviv, Israel
    Search for more papers by this author
  • Professor G. Dinari

    Corresponding author
    1. Division of Pediatric Gastroenterology, Beilinson Medical Center, Petah Tiqva, and the Tel Aviv University Sackler School of Medicine, Tel Aviv, Israel
    • Division of Pediatric Gastroenterology, Beilinson Medical Center, Petah Tiqva 49100, Israel
    Search for more papers by this author

Abstract

Two children with the Brachmann–de Lange syndrome and severe gastroesophageal reflux are described. Both had esophagitis, recurrent severe anemia, and one had recurrent episodes of aspiration pneumonia and clubbing. Medical treatment failed in both children. One child responded dramatically to surgery, but the other died before surgery could be attempted.

Our experience and a review of the literature suggest that early recognition and surgical treatment of gastroesophageal reflux will reduce morbidity and mortality in children with this syndrome.

Ancillary