Distal limb deficiency following chorionic villus sampling?
Article first published online: 3 JUN 2005
Copyright © 1992 Wiley-Liss, Inc., A Wiley Company
American Journal of Medical Genetics
Volume 42, Issue 3, pages 404–413, 1 February 1992
How to Cite
Schloo, R., Miny, P., Holzgreve, W., Horst, J. and Lenz, W. (1992), Distal limb deficiency following chorionic villus sampling?. Am. J. Med. Genet., 42: 404–413. doi: 10.1002/ajmg.1320420338
- Issue published online: 3 JUN 2005
- Article first published online: 3 JUN 2005
- Manuscript Revised: 18 NOV 1991
- Manuscript Received: 16 AUG 1991
- chorionic villus sampling;
- distal limb deficiency;
We have reviewed the follow-up of almost 3000 completed preganancies in the Münster CVS Program and identified 4 children with distal limb deficiencies. Two cases involved only minor anomalies of distal digital phalanges. One child had a Hanhart anomaly (hypoglossia hypodactylia).
We also reviewed 24 cases of limb defects following CVS reported previously. With the exception of a single series, neither the overall incidence of affected children nor cases reported from larger series provide unambiguous evidence of an increased risk of distal limb deficiency caused by CVS.