Craniosynostosis associated with partial duplication of 15q and deletion of 2q

Authors

  • M. I. Van Allen,

    Corresponding author
    1. Department of Medical Genetics, University Hospital-Shaughnessy Site and the University of British Columbia, Vancouver
    • Department of Medical Genetics, University Hospital-Shaughnessy Site, 4500 Oak Street, Vancouver, British Columbia, Canada V6H 3N1
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  • J. Siegel-Bartelt,

    1. Department of Medical Genetics, University Hospital-Shaughnessy Site and the University of British Columbia, Vancouver
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  • A. Feigenbaum,

    1. Department of Genetics, The Hospital for Sick Children, Toronto, Ontario, Canada
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  • I. E. Teshima

    1. Department of Genetics, The Hospital for Sick Children, Toronto, Ontario, Canada
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Abstract

We report on an infant with multiple congenital anomalies including complex craniosynostosis associated with an unbalanced karyotype, 46,XY, − 2, + der(2),t(2;15)(q37;q26)pat. The previous report of a child with cloverleaf skull and partial duplication of 15q25→qter and the Man-on-Mouse Homology map suggests that a critical segment for synostosis of sutures may be in this region. © 1992 Wiley-Liss, Inc.

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